Acellular dermis combined with sodium hyaluronate in the reconstruction of tendon sheath

doi:10.3969/j.issn.2095-4344.2014.43.009

Abstract

Abstract:

BACKGROUND: Acellular allogeneic dermis that is replaced by autologous tissue is not considered as foreign body, and can reduce local inflammation and cell infiltration, to achieve the possibility of permanent retention in the body after reconstruction of the tendon sheath.
OBJECTIVE: To evaluate the efficacy of acellular dermal matrix combined with sodium hyaluronate to prevent adhesiolysis after adhesions of tendon during the procedure of tendon sheath reconstruction.
METHODS: A total of 56 patients who required secondary adhesiolysis to repair tendon adhesions after repair of wrist tendon injury were randomly separated into experimental group (26 cases) and control group (30 cases). Experimental group: after tendon release, the sleeve-shaped acellular dermal matrix with a large diameter than the tendon was sewn into the site of tendon adhesions, 1 cm distant to the distal and proximal ends of non-adhesion tendon, to reconstruct the tendon sheath that was fixed at the both ends of surrounding tissue. Then, the incision was sutured after injection of sodium hyaluronate via the sleeve. Control group: after tendon release, the wound was sutured directly. All of the patients were followed-up for 6 months, to compare the efficacy of tendon release and reoccurrence of adhesions.
RESULTS AND CONCLUSION: For 51 tendons from 26 patients in the experimental group, valid treatment was in 49 tendons and invalid in 2 tendons, with the effective rate of 96%; for 58 tendons from 30 patients in the control group, effective treatment was in 46 tendons, and invalid in 12 tendons, with the effective rate of 79%. There was a significant difference in the effective rate between the two groups (P < 0.05). The reconstruction of tendon sheath using acellular dermal matrix combined with sodium hyaluronate can effectively improve adhesions after adhesiolysis.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: biocompatible materials, tissue adhesions

CLC Number:

R318

Cui Ze-long. Acellular dermis combined with sodium hyaluronate in the reconstruction of tendon sheath[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(43): 6940-6944.

Figures/Tables 1

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