Expression of myocardial heat shock protein under stress state

doi:10.3969/j.issn.2095-4344.2014.38.026

Abstract

Abstract:

BACKGROUND: Heat shock proteins have unique biological characteristics, and exploration of such proteins expressed in the myocardium under exercise stress has important value.
OBJECTIVE: To investigate the studies about the expression of myocardial heat shock proteins under stress condition, and analyze the expression characteristics of myocardial heat shock proteins under different stress conditions.
METHODS: A computer-based online retrieval was performed to find articles about the production, classification and function of heat shock proteins, as well as the expression of myocardial heat shock proteins published from January 1991 to January 2014 in PubMed database and Wanfang databases. The key words were “heat shock protein; myocardium; exercise stress” in English and Chinese. Finally 48 relevant articles were summarized.
RESULTS AND CONCLUSION: Heat shock proteins have the immune synergy effect. Researches show that, exercise training triggers the expression of myocardial heat shock protein. Acute exercise stress leads to a variety of physiological and biochemical changes, accordingly myocardial heat shock protein will make the corresponding expression and protect myocardial cells. Low-intensity exercise can increase the expression level of heat shock protein 72, and inhibit cardiomyocyte apoptosis. High-intensity exercise reduces the expression of heat shock protein 72, which can not effectively inhibit cardiomyocyte apoptosis and is not conducive to the myocardial protective effect. The expression of heat shock protein under moderate-intensity exercise remains controversial. Exercise-induced expression of heat shock protein may have protection effect against damage induced by exercise, moderate exercise activities play an important role in enhancing myocardial function and preventing myocardial injury.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: sports medicine, heat shock proteins, myocardium

CLC Number:

R318

Wan Li-li,Hu Ming-hua, Shi Shao-rong, Wu Chang-chu. Expression of myocardial heat shock protein under stress state[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(38): 6216-6221.

Figures/Tables 1

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