The association between angiotensin converting enzyme gene polymorphism and Alzheimer’s disease in Jiamusi region

doi:10.3969/j.issn.2095-4344.2014.02.016

Abstract

Abstract:

BACKGROUND: Angiotensin-converting enzyme as a key enzyme of the renin-angiotensin system, through the degradation effects of substance P mechanism, is involved in the occurrence and development of Alzheimer’s disease.
OBJECTIVE: To research the relationship between angiotensin-converting enzyme gene polymorphism and Alzheimer’s disease in Jiamusi region, as well as the effect of gender and hypertension on the relationship.
METHODS: This case-control study included 96 Alzheimer’s disease patients. Another 102 subjects served as controls coming from the same area and in the same environmental condition. DNA segments were amplified using PCR in 20 g/L agarose gel electrophoresis and observed under ultraviolet lamp. II, ID, DD genotypes and genotype frequencies were calculated for statistical analysis. On this basis, according to clinical data collected, we investigated association of Alzheimer’s disease with hypertension and gender.
RESULTS AND CONCLUSION: There was significant difference between Alzheimer’s disease patients and controls in angiotensin-converting enzyme genotypes and allele frequency. There was statistically significant difference between Alzheimer’s patients with hypertension and controls in angiotensin-converting enzyme genotypes and allele frequency. There was no statistical difference between Alzheimer’s disease patients with different genders and controls in angiotensin-converting enzyme genotypes and allele frequency. These findings indicate that there are some relationships between angiotensin-converting enzyme polymorphism and Alzheimer’s disease. II genotype is a risk factor for Alzheimer’s disease, angiotensin-converting enzyme II genotype is a risk factor for Alzheimer’s disease with hypertension.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: peptidyl-dipeptidase A, Alzheimer disease, genotype, gene frequency, hypertension

CLC Number:

R318

Zhang Shu-ping, Xuan Zhao-bo1, Huang Zuo-yi, Liu Ying-qin, Liu Qing, Wang Xiang-yu, Wu Cheng-ji, Yang Li-min, Zeeshan Abbas . The association between angiotensin converting enzyme gene polymorphism and Alzheimer’s disease in Jiamusi region[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(2): 259-264.

Figures/Tables 3

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