Simvastatin compounded with Bio-Oss repairs rabbit mandibular defects

doi:10.3969/j.issn.2095-4344.2013.48.013

Abstract

Abstract:

BACKGROUND: Studies have shown that simvastatin can promote bone formation, but there is still controversial on the osteogenic mechanism and osteogenic effect.
OBJECTIVE: To explore the osteogenesis effect of the composite of simvastatin and Bio-Oss versus simple Bio-Oss material on the repair of rabbit mandibular defects.
METHODS: Twelve New Zealand white rabbits were selected to establish alveolar bilateral mandibular defects models. The composite of simvastatin and Bio-Oss was implanted randomly in one side of defect region; Bio-Oss was simply implanted in the other side of defect region. Both sides were covered with Bio-Gide bilayer collagen membrane. Four rabbits in each group were sacrificed at 4, 8 and 12 weeks after implantation, and the general observation X-ray film, oral cone-beam CT imaging observation and histopathologic study and quantitatively were conducted to quantitatively and qualitatively comparative analyze the alveolar bone formation in the graft region.
RESULTS AND CONCLUSION: At 4, 8 and 12 weeks after implantation, new bone formation was found and increased with time prolonging. With the gradual degeneration of high resistance fire Bio-Oss bone meal, the bone mineral density at different time points of the simvastatin composite Bio-Oss group was lower than that of the simple Bio-Oss group (P < 0.05). The percentage of bone formation in the simvastatin composite Bio-Oss group was significantly higher than that in the simple Bio-Oss group (P < 0.05). Simvastatin could accelerate Bio-Oss degradation and promote new bone formation in bone defects repairing.

Key words: bone regeneration, guided tissue regeneration, mandible, osteogenesis

CLC Number:

R318

Wang Yang, Jiao Xin, Liang Heng-yan, Ge Zhen-lin. Simvastatin compounded with Bio-Oss repairs rabbit mandibular defects[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(48): 8374-8380.

Figures/Tables 6

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