Chinese Journal of Tissue Engineering Research ›› 2013, Vol. 17 ›› Issue (41): 7323-7328.doi: 10.3969/j.issn.2095-4344.2013.41.021

Previous Articles     Next Articles

Cholecystokinin and nerve repair

Chen Xuan-huang, Hu Li-bin, Li Rong-yi, Cai Han-hua   

  1. Department of Orthopedics, Affiliated Hospital of Putian University, Putian  351100, Fujian Province, China
  • Received:2013-06-18 Revised:2013-08-07 Online:2013-10-08 Published:2013-11-01
  • Contact: Li Rong-yi, Chief physician, Associate professor, Department of Orthopedics, Affiliated Hospital of Putian University, Putian 351100, Fujian Province, China
  • About author:Chen Xuan-huang★, Master, Attending physician, Department of Orthopedics, Affiliated Hospital of Putian University, Putian 351100, Fujian Province, China ptyygk@163.com
  • Supported by:

    the General Class A Scientific Program of Fujian Educational Department, No. JA11212*; the Medical Plan of Putian City, No. 2012S03(4)*

Abstract:

BACKGROUND: In the past 20 years, cholecystokinin in clinical application and nerve repair has been extensively studied.
OBJECTIVE: To explore the role of cholecystokinin in nerve repair and its possible mechanism of action.
METHODS: Relevant research results were retrospectively analyzed at the cell and organ levels through retrieving recent literatures concerning the biological characteristics of cholecystokinin and its biological role in the nervous system. Then, we summarized the effect of cholecystokinin after nerve injury and its possible mechanism of action.
RESULTS AND CONCLUSION: Cholecystokinin and its receptors are widely distributed in the body, and under physiological and pathological conditions, their roles were complex and diverse. However, studies addressing the neuroprotective effect of cholecystokinin are not sufficient, most of which are limited to phenomenon observation. Neuroprotective mechanism of cholecystokinin is still worthy of further studies, which can provide the basis for the clinical application.

Key words: cholecystokinin, receptor, cholecystokinin A, receptor, cholecystokinin B, tetragastrin

CLC Number: