Preparation of gelatin-magnetic micro-capsules by condensation method

doi:10.3969/j.issn.2095-4344.2013.29.015

Abstract

Abstract:

BACKGROUND: Compared with conventional medications, drug micro-capsule system can control the release of drugs and have well target properties and biocompatibility. The drugs can be concentrated at the focus and play an important role in clinic.
OBJECTIVE: To prepare dacarbazine magnetic micro-capsules with different capsule materials and gelatin complex by coacervation, and to optimize capsule materials and preparation process.
METHODS: Fe3O4 magnetic materials were prepared with chemical coprecipitation method. With the solution complex coacervation, we prepared the gelatin-Arabic gum magnetic micro-capsule, gelatin-sodium alginate magnetic micro-capsules, gelatin-sodium carboxymethyl cellulose magnetic micro-capsules, and gelatin-chitosan magnetic micro-capsules. With the emulsion complex coacervation method, we further prepared the gelatin-Arabic gum magnetic micro-capsule, gelatin-sodium alginate magnetic micro-capsules, gelatin-sodium carboxymethyl cellulose magnetic micro-capsules, and gelatin-chitosan magnetic micro-capsules. The magnetic gelatin micro-capsules and magnetic chitosan micro-capsules were prepared with single coagulation method. The micro-capsules were determined for the embedding rate, the magnetic susceptibility, the micro-capsule size and the release performance, to define the optimal preparation technology of dacarbazine magnetic micro-capsules.
RESULTS AND CONCLUSION: The solution complex coacervation method was better than the emulsion coacervation method. As for the solution complex coacervation method, the optimal capsule material was gelatin-sodium alginate, with drug embedding rate 37.90%, the yield rate 72.31%, and the average magnetization intensity 8.53 emu/g. The second material was gelatin-chitosan. As a capsule material, the gelatin was better than chitosan with single coagulation method. Drug embedding rate was 51.58%, the yield rate was 64.50%, and the average magnetization was 6.93 emu/g. Single coagulation method was better than coacervation method.

Key words:

biomaterials, biomaterials and controlled drug release, complex coacervation, gelatin, sodium alginate, chitosan, slow-release micro-capsules, magnetic performance, preparation method, accumulated release, provincial grants-supported paper

CLC Number:

R318

Xian Yuan-fang, Wang Wen-ting, Yu Wei, Tu Li-hui, Wang Sheng-hai, Zou Cheng, Min Xiao-feng. Preparation of gelatin-magnetic micro-capsules by condensation method[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(29): 5357-5363.

Figures/Tables 6

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