Fresh frozen plasma transfusion for the treatment of hyponatremia after cervical spinal cord injury

doi:10.3969/j.issn.2095-4344.2013.17.024

Abstract

Abstract:

BACKGROUND: Studies have shown that fresh frozen plasma has comprehensive treatment value in clinic, such as anti-shock, immunology, hemostasis and detoxification, and it can correct the colloid osmotic pressure. Complementing the fresh frozen plasma during water limitation and sodium supplement can increase the sodium levels in patients with spinal cord injury, which provide a new breakthrough for hyponatremia after clinical treatment of spinal cord injury.
OBJECTIVE: To establish a rabbit model of cervical spinal cord injury combined with hyponatremia, and to observe the effectiveness of fresh frozen plasma transfusion for hyponatremia after cervical spinal cord injury.
METHODS: Sixty healthy adult rabbits subjected a Allen’s punch method to establish rabbit models of cervical spinal cord injury. Forty survived and hyponatremia rabbits were randomly divided into two groups: control group and experimental group, 20 rabbits in each group, and then each group was divided into 1, 3, 6, 10 and 15 days group according to time for taking the specimens, a total of 10 sub-groups and 4 rabbits in each sub-group. The rabbits in the experimental group were injected with 20 mL fresh frozen plasma at 24 hours after hyponatremia appeared (1 day group was injected for one time, 3 days sub-group was injected for three times, 6 days sub-group was injected for six times, 10 days sub-group was injected for 10 times and the 15 days sub-group was injected for 15 times). The rabbits in the control group were injected with 20 mL normal saline every 24 hours. The specimens in each group were taken before operation and 24 hours after fresh frozen plasma transfusion to detect the sodium ions in the plasma and spinal tissue.
RESULTS AND CONCLUSION: Sodium concentration in plasma and spinal cord of the control group and experimental group at 3 and 6 days after operation was significantly decreased when compared with that before operation (P < 0.05). Sodium concentration in plasma and spinal cord of the experimental group at 10 and
15 days after operation was increased, while the control group was decreased continuously, and there was significant difference of sodium concentration between control group and experimental group (P < 0.05). Sodium concentration in the spinal cord of the control group and experimental group at 3 and 6 days after operation was significantly increased when compared with that of the blank control group (P < 0.05). Sodium concentration in the spinal cord of the experimental group was returned to normal level after fresh frozen plasma injected for 10 days, while the sodium concentration of the control group was increased continuously, there was significant difference of sodium concentration in the spinal cord between the control group and the experimental group (P < 0.05). Hyponatremia is a common complication after cervical spinal cord injury. Fresh frozen plasma transfusion is a good way to treat hyponatremia after acute cervical spinal cord injury.

Key words: bone and joint implants, basic experiment of spinal injury, hyponatremia, spinal cord injury, fresh frozen plasma, rabbit, model, treatment, sodium concentration, nerve injury, correction, spinal cord

CLC Number:

R318

Zhang Sheng-fei, Wang Yong-xiang, Feng Xin-min, Tao Yu-ping. Fresh frozen plasma transfusion for the treatment of hyponatremia after cervical spinal cord injury[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(17): 3223-3230.

Figures/Tables 4

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