Adipose-derived stem cells assisted facial rejuvenation

doi:10.3969/j.issn.2095-4344.2012.49.025

Abstract

Abstract:

BACKGROUND: Several studies have demonstrated that adipose-derived stem cells have tissue reparative ability, but few studies have been reported about application of adipose-derived stem cells in facial rejuvenation treatment.
OBJECTIVE: Primary adipose-derived stem cells were isolated from human liposuction aspirates and added into adipose tissue. The compounds were injected into the face of patients who underwent face lifting through tempus incision. The aesthetic effects were observed.
METHODS: Clinical data of 20 female patients who underwent fact lifting between June 2009 and August 2011 in Department of Plastic Surgery, General Hospital of Shenyang Military Command were retrospectively analyzed. Ten patients who received autologous adipose-derived stem cells assisted treatment were included in the treatment group, and the remaining 10 patients who underwent simple facial lifting were included in the control group. The therapeutic effects were evaluated using score of wrinkle standard and VISIA professional skin image analysis system in terms of freckle, pores, wrinkle, and skin texture.
RESULTS AND CONCLUSION: Twenty patients were followed by 3-15 months. There was no significant difference in the score of wrinkle standard between treatment and control groups (P > 0.05). It suggests that autologous adipose-derived stem cells assisted treatment and simple face lifting have no obvious difference in reducing the wrinkles. VISIA skin detection results showed that there was a greater improvement in freckle and pores in the treatment group compared with the control group (P < 0.05) and there was no significant difference in improvement in skin texture and wrinkles (P > 0.05). These results suggest that autologous adipose-derived stem cells assisted treatment and simple face lifting have similar effects in facial rejuvenation, but the former exhibits better effects than the latter one on improving pores and freckle.

CLC Number:

R394.2

Tian Ya-guang, Liu Xiao-yan, Tao Kai, Huang Wei, Liang Jiu-long, Yu Kun. Adipose-derived stem cells assisted facial rejuvenation[J]. Chinese Journal of Tissue Engineering Research, 2012, 16(49): 9257-9264.

Figures/Tables 5

References

[1] Antell DE, Orseck MJ. A comparison of face lift techniques in eight consecutive sets of identical twins. Plast Reconstr Surg. 2007;120(6):1667-1673.

[2] Pessa JE, Zadoo VP, Mutimer KL, et al. Relative maxillary retrusion as a natural consequence of aging: combining skeletal and soft-tissue changes into an integrated model of midfacial aging. Plast Reconstr Surg. 1998;102(1): 205-212.

[3] Pessa JE, Zadoo VP, Adrian EK, et al. Variability of the midfacial muscles: analysis of 50 hemifacial cadaver dissections. Plast Reconstr Surg. 1998;102(6):1888- 1893.

[4] Sutton DN, Lewis BR, Patel M, et al. Changes in facial form relative to progressive atrophy of the edentulous jaws. Int J Oral Maxillofac Surg. 2004;33(7):676-682.

[5] Pessa JE, Zadoo VP, Yuan C, et al. Concertina effect and facial aging: nonlinear aspects of youthfulness and skeletal remodeling, and why, perhaps, infants have jowls. Plast Reconstr Surg. 1999;103(2):635-644.

[6] Ramirez OM. Full face rejuvenation in three dimensions: a “face-lifting” for the new millennium. Aesthetic Plast Surg. 2001;25(3):152-164.

[7] Lin XX. Zhongguo Meirong Zhengxing Waike Zazhi. 2008; 19(5):321-324.林晓曦.面部年轻化的激光治疗进展与评价[J].中国美容整形外科杂志,2008,19(5):321-324.

[8] Babilas P, Schreml S, Szeimies RM, et al. Intense pulsed light (IPL): a review. Lasers Surg Med. 2010;42(2):93-104.

[9] Fodor L, Carmi N, Fodor A, et al. Intense pulsed light for skin rejuvenation, hair removal, and vascular lesions: a patient satisfaction study and review of the literature. Ann Plast Surg. 2009;62(4):345-349.

[10] Alster TS, Lupton JR. Nonablative cutaneous remodeling using radiofrequency devices. Clin Dermatol. 2007;25(5): 487-491.

[11] Gao JH, Bai LM, Li MQ. Zhongguo Meirong Zhengxing Waike Zazhi. 2006;17(4):290-293.高景恒,白伶珉,李孟倩.射频技术在美容外科应用中的进展[J].中国美容整形外科杂志,2006,17(4):290-293.

[12] Elsale ML, Choudhary S, Leiva A, et al. Nonablative radiofrequency for skin rejuvenation. Dermatol Surg. 2010; 36(5):577-589.

[13] Choi YJ, Lee JY, Ahn JY, et al. The safety and efficacy of combined diode laser and bipolar radiofrequency compared with combined infrared light and bipolar radiofrequency for skin rejuvenatio. Indian J Dermatol Venereol Leprol. 2012; 78(2):146-152.

[14] Wu SF, Shi HY, Yan S, et al. Zhongguo Meirong Zhengxing Waike Zazhi. 2007;18(5):324-328.吴溯帆,石杭燕,严晟,等.透明质酸在面部美容中的应用[J].中国美容整形外科杂志,2007,18(5):324-328.

[15] Lupo MP. Hyaluronic acid fillers in facial rejuvenation. Semin Cutan Med Surg. 2006;25(3):122-126.

[16] Kelly PE. Injectable success: from fillers to Botox. Facial Plast Surg. 2007;23(1): 7-18.

[17] von Heimburg D, Hemmrich K, Zachariah S, et al. Oxygen consumption in undifferentiated versus differentiated adipogenic mesenchymal precursor cells. Respir Physiol Neurobiol. 2005;146(2-3):107-116.

[18] Yoshimura K, Asano Y, Aoi N, et al. Progenitor-enriched adipose tissue transplantation as rescue for breast implant complications. Breast J. 2010;16(2):169-175.

[19] Yoshimura K, Suga H, Eto H. Adipose-derived stem/progenitor cells: roles in adipose tissue remodeling and potential use for soft tissue augmentation. Regen Med. 2009; 4(2):265-273.

[20] Yoshimura K, Sato K, Aoi N, et al. Cell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells. Dermatol Surg. 2008;34(9): 1178-1185.

[21] Yoshimura K, Sato K, Aoi N, et al. Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose-derived stem/stromal cells. Aesthetic Plast Surg. 2008;32(1):48-55; discussion 56-57.

[22] Yoshimura K, Aoi N, Suga H, et al. Ectopic fibrogenesis induced by transplantation of adipose-derived progenitor cell suspension immediately after lipoinjection. Transplantation. 2008;85(12):1868-1869.

[23] Li J, Gao JH, Lu F, et al. Zhonghua Zhengxing Waike Zazhi. 2009;25(2):129-133.李劼,高建华,鲁峰,等.脂肪组织来源干细胞提高游离脂肪移植存活率的研究[J].中华整形外科杂志,2009,25(2):129-133.

[24] Liu XY, Tao K, Liang JL, et al. Zhongguo Meirong Zhengxing Waike Zazhi. 2010;21(11):647-649.刘晓燕,陶凯,梁九龙,等.脂肪源性干细胞在面部整形美容中的应用:15例临床报告[J].中国美容整形外科杂志,2010,21(11):647- 649.

[25] Fu BC, Gao JH, Lu F, et al. Zhonghua Zhengxing Waike Zazhi. 2010;26(4):289-294.付冰川,高建华,鲁峰,等.新鲜分离的脂肪SVF细胞促进脂肪移植存活的实验研究[J].中华整形外科杂志,2010,26(4):289-294.

[26] Yuan ZW, Yang PY, Feng GZ. Zhonghua Zhengxing Waike Zazhi. 1999;15(4):271-273.袁志伟,杨佩瑛,冯光珍.鼻唇沟除皱术的局部解剖学与临床应用研究[J].中华整形烧伤外科杂志,1999,15(4):271-273.

[27] Yan YJ, Qiao Q, Wang XJ, et al. Zhongguo Shiyong Meirong Zhengxing Waike Zazhi. 2006;17(3):164-166.闫迎军,乔群,王晓军,等.个性化治疗面部老化的观察研究[J].中国实用美容整形外科杂志,2006,17(3):164-166.

[28] Carruthers JD, Carruthers JA. Treatment of glabellar frown lines with C. botulinum-A exotoxin. J Dermatol Surg Dncol. 1992;18(1):17-21.

[29] Liu XY, Huang W, Qiu T, et al. Zhongguo Meirong Zhengxing Waike Zazhi. 2007;18(6):414-418.刘晓燕,黄威,邱涛,等.颧颊部解剖学研究与“佛手”式颧颊纤维脂肪垫连续悬吊术矫正面中下部老化松垂[J].中国美容整形外科杂志,2007,18(6):414-418.

[30] State Council of the People's Republic of China. Administrative Regulations on Medical Institution. 1994-09-01.

[31] Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7(2):211-228.

[32] Zhonghua Yixuehui.Beijing:Renmin Junyi Chubanshe. 2004.中华医学会.临床技术操作规范整形外科分册[M].北京:人民军医出版社,2004.

[33] Xie Y, Zheng DN, Liu K, et al. Zhonghua Zhengxing Waike Zazhi. 2010;26(3):178-181.谢芸,郑丹宁,刘凯,等.自体脂肪移植综合技术在面部轮廓整形中的应用[J].中华整形外科杂志,2010,26(3):178-181.

[34] Beer K, Beer J. Overview of facial aging. Facial Plast Surg. 2009;25(5):281-284.

[35] Cariou JL. Midface and its rejuvenation. Ann Chir Plast Esthet. 2009;54(5):397-398.

[36] Rigotti G, Marchi A, Galiè M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg. 2007;119(5):1409-1422.

[37] Nambu M, Kishimoto S, Nakamura S, et al. Accelerated wound healing in healing-impaired db/db mice by autologous adipose tissue-derived stromal cells combined with atelocollagen matrix. Ann Plast Surg. 2009;62(3):317-321.

[38] Kim WS, Park BS, Park SH, et al. Antiwrinkle effect of adipose-derived stem cell: activation of dermal fibroblast by secretory factors. J Dermatol Sci. 2009;53(2):96-102.

[39] Sung HM, Suh IS, Lee HB, et al. Case reports of adipose-derived stem cell therapy for nasal skin necrosis after filler injection. Arch Plast Surg. 2012;39(1):51-54.

[40] Chan PK, Zamora DO, Wrice NL, et al. Development of a vascularized skin construct using adipose-derived stem cells from debrided burned skin. Stem cells Int. 2012;2012:841203

[41] Tao K, Liu XY. Zhongguo Meirong Zhengxing Waike Zazhi. 2011;22(5):303-306.陶凯,刘晓燕.脂肪源性干细胞的临床前期研究与临床应用[J].中国美容整形外科杂志,2011,22(5):303-306.