Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (48): 9096-9100.doi: 10.3969/j.issn.2095-4344.2012.48.032

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Impacted bone graft in a titanium mesh for reconstructing segmental defect of limb long bone

Yin Qu-dong, Gu San-jun, Sun Zhen-zhong, Rui Yong-jun, Shou Kui-shui   

  1. Department of Orthopedics, Wuxi Ninth People’s Hospital, Wuxi 214062, Jiangsu Province, China
  • Received:2012-01-29 Revised:2012-03-31 Online:2012-11-25 Published:2013-03-14
  • About author:Yin Qu-dong☆, Doctor, Chief physician, Department of Orthopedics, Wuxi Ninth People’s Hospital, Wuxi 214062, Jiangsu Province, China yinqudong@sina.com

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Abstract:

BACKGROUND: Segmental defect of limb long bone is common in clinic, which has long been a problem in the field of reconstruction and repair of bone.
OBJECTIVE: To introduce a new method of impacted bone graft in a titanium mesh for reconstructing segmental defect of limb long bone, including its experimental research and clinical applications.
METHODS: The PubMed database (http://www.ncbi.nlm.nih.gov/PubMed), CNKI database (www.cnki.net/index.htm), VIP database (http//www.cqvip.com/) between 1990 and 2011 were searched by the first author for the articles relate to impacted bone graft in a titanium mesh for reconstructing segmental defect of limb long bone. The English key words were “segmental bone defect, titanium mesh or titanium cage” and the Chinese key words were “limbs or lone bone, segmental bone defect, titanium mesh or titanium cage”. The repetitive studies, non-limb long bone and Meta-analysis articles were excluded. According to the inclusion and exclusion criteria, a total of 30 literatures were included to review.
RESULTS AND CONCLUSION: Impacted bone graft in a titanium mesh for reconstructing segmental defect of limb long bone have achieved good results for bone formation in both large and small animal experiments, which was superior to free bone graft without titanium mesh and free large cortical bone graft. Autologous bone, allograft bone and artificial bone are feasible materials for bone graft, but autogenous cancellous bone is relatively better and bioactive titanium mesh of the autogenous cancellous bone is better than general titanium mesh. Clinically, it has achieved good therapeutic effect in all parts of long bone segmental bone defects, including long bone defect cases that more than 10 cm. The impacted bone graft in a titanium mesh for reconstructing segmental defect of limb long bone is a new method, which changed the old view of more than 6 cm long bone defect is only suitable for vascularized bone graft, not suitable for non-vascularized free bone graft. It is relatively simple, safe and effective, and it is an ideal non-vascularized free bone graft for the treatment of segmental long bone defects.

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