Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (48): 9015-9019.doi: 10.3969/j.issn.2095-4344.2012.48.016

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Meta-analysis on the association between medial tibial plateau slope angle and anterior cruciate ligament injuries

Zeng Chao1, Wei Jie2, Gao Shu-guang1, Lei Guang-hua1, Zhu He-yuan1, Zhang Kai1   

  1. 1Department of Orthopedics, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
    2School of Public Health of Central South University, Changsha 410008, Hunan Province, China
  • Received:2012-01-18 Revised:2012-03-08 Online:2012-11-25 Published:2013-03-14
  • Contact: Lei Guang-hua, Doctor, Professor, Doctoral supervisor, Department of Orthopedics, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China Lgh9640@sina.com
  • About author:Zeng Chao★, Studying for master’s degree, Department of Orthopedics, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China 125562108@qq.com

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Abstract:

BACKGROUND: As an anatomy associated risk factors of the anterior cruciate ligament injury, medial tibial plateau slope angle has been attracted much more attention, but as for the correlation between the anterior cruciate ligament injury and medial tibial plateau slope angle presence or absence, the results of the studies are not the same.
OBJECTIVE: To determine the association between medial tibial plateau slope angle and anterior cruciate ligament injuries, and to investigate gender differences between anterior cruciate ligaments injured subjects and gender-matched controls.
METHODS: The Cochrane library, Medline database, Elsevier database, Chinese Biomedical database and Wanfang database were retrieved by computer and the hand research of relevant literatures was performed. The deadline of all the retrieves was 2011-11-01. We included case-control and sectional studies on the association between medial tibial plateau slope angle and anterior cruciate ligament injury. The STATA11.0 software package was used for data-analysis.
RESULTS AND CONCLUSION: Twelve trails with 1 823 objects were included for Meta analysis (888 objects in injury group and 925 objects in control group). For the whole objects in the injury group and control group, the pooled weighted mean difference for medial tibial plateau slope angle was 1.06, 95% confidence interval (CI) (0.36, 1.76), and P < 0.05. Subgroup analysis showed that, for the male objects, the pooled weighted mean difference for medial tibial plateau slope angle in the injury group and the control group was 0.84,95%CI:(-0.03,1.70) and P > 0.05. For the female objects, the pooled weighted mean difference for medial tibial plateau slope angle was 1.62, 95%CI (0.72, 2.52) and P < 0.05. The results of this Meta-analysis suggest that increased medial tibial plateau slope appears to contribute to anterior cruciate ligament injuries in females, but not in males.

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