Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (46): 8589-8592.doi: 10.3969/j.issn.2095-4344.2012.46.008

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Guided bone regeneration repairs human mandibular bone defects: Histological observation

Chen Hong-liang1, Zhao Cheng-chu2, Sun Yong2, Zhao Feng2, Zhong Ke2   

  1. 1Stomatological School of Luzhou Medical College, Luzhou 646000, Sichuan Province, China
    2Department of Stomatology, the Hospital Affiliated to Chengdu Military Region, Chengdu 610011, Sichuan Province, China
  • Received:2012-10-15 Revised:2012-10-20 Online:2012-11-11 Published:2013-03-16
  • Contact: Sun Yong, Chief physician, Department of Stomatology, the Hospital Affiliated to Chengdu Military Region, Chengdu 610011, Sichuan Province, China Chl1976sxl@163.com
  • About author:Chen Hong-liang★, Studying for master’s degree, Stomatological School of Luzhou Medical College, Luzhou 646000, Sichuan Province, China

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Abstract:

BACKGROUND: Osteogenesis effects of guided bone regeneration have been verified in basic research and animal experiments. However, histological observation of bone regeneration following repair of human mandibular bone defects using guided bone regeneration is not reported in China.
OBJECTIVE: To study the osteogenesis effects of guided bone regeneration on the repair of human mandibular bone defects through histological observation.
METHODS: Twenty-four defects from 19 mandibular bone defect patients were subjected to guided bone regeneration therapy. After 6 months, dental implantation was performed. New bone tissues in the surgical area were taken using a hollow drill for histological observation and osteogenesis evaluation.
RESULTS AND CONCLUSION: Different developmental stages of bone formation were visible in new bone tissues. Lamellar bone tissues were mainly found near the root apex, while fibrous bone tissues containing osteoid tissue and cartilage bone formed at the dental crown. It indicated that there is a certain 6-month osteogenesis effect of guided bone regeneration, but the long-term effect needs further observation.

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