Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (46): 8566-8570.doi: 10.3969/j.issn.2095-4344.2012.46.004

Previous Articles     Next Articles

Miao Nationality’s Jiuxianluohanjiegu decoction promotes tibial shaft fracture healing

Yang Yan-jun1, Xiong Yi2, Cheng Zhi-gang2, Tang Liang-hua2     

  1. 1Guiyang College of Traditional Chinese Medicine, Guiyang 550002, Guizhou Province, China
    2Department of Orthopedics, the Second Affiliated Hospital of Guiyang College of Traditional Chinese Medicine, Guiyang 550003, Guizhou Province, China
  • Received:2012-03-03 Revised:2012-07-30 Online:2012-11-11 Published:2013-03-16
  • Contact: Tang Liang-hua, Doctor, Associate chief physician, Department of Orthopedics, the Second Affiliated Hospital of Guiyang College of Traditional Chinese Medicine, Guiyang 550003, Guizhou Province, China tlhyyd@21cn.com
  • About author:Yang Yan Jun★, Studying for master’s degree, Physician, Guiyang College of Traditional Chinese Medicine, Guiyang 550002, Guizhou Province, China yangyanjun223537@sohu.com

PDF

529

Abstract:

BACKGROUND: Clinical researches have shown that Miao Nationality’s Jiuxianluohanjiegu decoction has the effect of promoting the blood circulation, remove blood stasis and obstruction, and reunion of bone, detumescence and analgesia, but the report on the effect in promoting the fracture healing is rare.
OBJECTIVE: To observe the effect of Miao Nationality’s Jiuxianluohanjiegu decoction in promoting the rabbit tibial shaft fracture healing.
METHODS: Using traditional Chinese medicine method of decocting, preparing experiment required concentration of decoction, millipore filtration standby. New Zealand rabbit white right tibialis anterior disruption caused by width 3 mm and depth 2 mm of the bone defect model, and the models were randomly divided into three groups; Jiegu decoction group, Sanqi control group, normal saline group. The rabbits in the three groups were gavaged with Miao Nationality’s Jiuxianluohanjiegu decoction, Sanqi powder and liquid and normal saline respectively. All the rabbits were administrated since fracture, and the whole blood viscosity, plasma viscosity, red blood cells deposited, blood calcium, serum phosphorus, alkaline phosphatase concentration, X-ray score and pathological changes were measured at 1, 7, 14, 21 and 28 days after administration.
RESULTS AND CONCLUSION: Compared with Sanqi control group and normal saline group, the blood calcium, serum phosphorus and alkaline phosphatase concentration in the Jiegu decoction group were increased and reached to peak early, then gradually decreased (P < 0.05), while the hemorheology indicators were gradually decreased (P < 0.05). X-ray score half quantitative analysis showed that the fracture healing of the Jiegu decoction group was faster than that of the Sanqi control group and normal saline group, and the difference was significant (P < 0.05). Hematoxylin-eosin staining revealed that the callus formation speed and quality in the Jiegu decoction group were much higher than those in the other two groups. Miao Nationality’s Jiuxianluohanjiegu decoction can promote the callus formation and shorten the fracture healing time.

CLC Number: