Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (31): 5875-5880.doi: 10.3969/j.issn.2095-4344.2012.31.035

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Ovarian tissue cryopreservation and transplantation technology

Sun Yu1, Li Qing2, Zhu Jiang3   

  1. 1Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;
    2Medical Center, West China Medical School, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;
    3Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2012-01-29 Revised:2012-04-13 Online:2012-07-29 Published:2012-07-29
  • Contact: Zhu Jiang, Master, Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China zhujiang1@medmail.com.cn
  • About author:Sun Yu, Physician, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China syjjbaby@sohu.com

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Abstract:

BACKGROUND: Fertility preservation techniques can provide the opportunity to restore the endocrine function and reproductive function for the female patients that loss of ovarian function due to tumor or cancer treatment-related causes.
OBJECTIVE: To review the progress and problem on the application of vitrification freeze of ovarian tissues and freeze-thaw ovarian tissue autograft in reconstruction of ovary function.
METHODS: A computer-based search was performed on the CNKI database and PubMed database from January 1999 to December 2011 for the articles about premature ovarian failure. The key words were “premature ovarian failure, vitrification freeze, ovary transplantation” in English and Chinese. Finally, 40 articles relate to the vitrification freeze of ovarian tissues and freeze-thaw ovarian tissue autograft were included to review.
RESULTS AND CONCLUSION: As for the methods to reconstruct the ovary function of tumor related premature ovarian failure patient, both methods that vitrification freeze of ovarian tissues and freeze-thaw ovarian tissue autograft have bright future in clinical application, which can not only restore natural fertility, genital function and endocrine function, but also are safe and convenient without immunological rejection or ethnics disputes. It is believed that the technique of ovarian tissue cryopreserved transplantation will be more advanced along with the development of the medical research in the future, and it will raise hopes by reconstructing their fertility and endocrine function for those female patients suffering from tumor.

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