Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (31): 5861-5870.doi: 10.3969/j.issn.2095-4344.2012.31.033

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Development trends of research on the rejection after liver transplantation in China

Hu Xu-guang, Nan Jin-niang, Li Hong-xiu   

  1. Second People’s Hospital of Panjin, Panjin 124000, Liaoning Province, China
  • Received:2012-03-30 Revised:2012-03-30 Online:2012-07-29 Published:2012-07-29
  • Contact: 李洪秀，博士，主任医师，硕士生导师，盘锦市第二人民医院，辽宁省盘锦市 124000 lihongxiu666@ sina.com
  • About author:Hu Xu-guang★, Master, Attending physician, Second People’s Hospital of Panjin, Panjin 124000, Liaoning Province, China cstle106@yahoo. com.cn

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Abstract:

BACKGROUND: Patients with end-stage liver disease can be treated through whole liver transplantation or part liver transplantation. With the occurrence of new immunosuppressive drugs, the incidence rate of rejection after liver transplantation is significantly decreased, and the survival rate of patients is improved.
OBJECTIVE: To analyze the literatures on the rejection after liver transplantation from multi-level aspects.
METHODS: A computer-based research was performed on the CNKI database and China Doctoral Dissertations Full-text Database from January 2002 to December 2011 for the literatures related to rejection after liver transplantation. The key words were “liver transplantation, rejection”. The character of the data was analyzed by the analysis capabilities of the database and Excel chart function.
RESULTS AND CONCLUSION: In the CNKI database from 2002 to 2011, a total of 777 literatures that related to the rejection after liver transplantation were screened out. From the quantitative of the literature, the number of the literature in 2006 reached to peak (110 literatures), and number was in the upward trend before the promulgation of Human Organ Transplant Ordinance in 2007, and then the number of the literature was decreased. There was a large amount of foundation, among the literatures, 210 literatures supported by 39 foundations, the number of provincial funded project was 28 and the number of the foundation from Guangdong province was up to 4. Chinese Journal of Organ Transplantation is the authoritative journal of rejection after liver transplantation in China. The research on the rejection after liver transplantation was mainly depend on the animal experiment of rat, and the research found that the incidence of acute rejection after transplantation is relatively high, and the research on the potent new immunosuppressant was mainly based on tacrolimus. A total of 90 literatures were screened out in the China Doctoral Dissertations Full-text Database, the number of the literature, subject category, research institutions, key words and the foundation project were similar to those in CNKI database.

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