Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (31): 5853-5860.doi: 10.3969/j.issn.2095-4344.2012.31.032

Previous Articles     Next Articles

Clinical application of immunosuppressive agents in corneal graft rejection

Wang Yang1, Xing Chun-sheng2, Zhou Xing1, Wang Lei1, Han Hong-guang3   

  1. 1Department of Ophthalmology, Shenxiang No. 705 Hospital, Shenyang 110015, Liaoning Province, China;
    2Out-patient Department of Liaoning Military Region, Shenyang 110032, Liaoning Province, China;
    3Department of Cardiovascular Surgery, General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province, China
  • Received:2012-01-06 Revised:2012-06-08 Online:2012-07-29 Published:2012-07-29
  • Contact: Han Hong-guang, Doctor, Associate chief physician, Master’s supervisor, Department of Cardiovascular Surgery, General Hospital of Shenyang Military Region, Shenyang 110016, Liaoning Province，China hanxiyao@163.com
  • About author:Wang yang★, Master, Attending physician, Department of Ophthalmology, Shenxiang No. 705 Hospital, Shenyang 110015, Liaoning Province, China xuemianyang@sina.com

PDF

546

Abstract:

BACKGROUND: Immune rejection of corneal transplantation is a complex reaction, typically including leukocyte antigen sensitization and host response to allogeneic tissue antigens. The failure of corneal transplantation is mainly due to immune rejection. Effective prevention of corneal allograft rejection in the eye treatment is a practical problem to be solved.
OBJECTIVE: To analyze the application of immunosuppressive agents in corneal graft rejection.
METHODS: A retrieval was performed for articles addressing the application and effect of immunosuppressive agents in corneal graft rejection, using key words of “keratoplasty/corneal transplantation, immunological rejection, immunosuppressant, cyclosporine A, tacrolimus, rapamycin” in Scopus database (2002/2011).
RESULTS AND CONCLUSION: Immune rejection involves multiple factors. High-risk corneal diseases, such as high-vascularized cornea, infectious corneal ulcer, repeat transplantation, particularly increase the probability of rejection and result in an earlier occurrence of rejections, moreover, the time span is longer after surgery. Corneal transplantation rejection is a complex process, and we have made progress in its prevention and treatment. However, the rejection is still the leading cause of corneal graft failure. The experts are constantly trying to apply the new drugs and treatment measures to improve the corneal graft survival, in order to make the receptor to maintain a normal immune response inducing or establishing donor-specific immune tolerance. Immunosuppressive agents in corneal graft rejection are indispensable. This paper provides a valuable reference for researchers to understand the overview and present situation of this field.

CLC Number: