Abstract:

BACKGROUND: Cycloxygenase-2 is the enzyme closely related to inflammatory reaction. Its expression may be associated with stenosis of grafted vein.
OBJECTIVE: To study the cycloxygenase-2 expression in the transplanted vein, and to investigate the relevance between cycloxygenase-2 expression and stenosis of grafted vein.
METHODS: The experiment was divided into two groups. The autogenously vein graft rabbit models were established in two groups, and the models in the experimental group were intervened by cycloxygenase-2 inhibitors and the models in the control group were fed normally after modeling. The cycloxygenase-2 expression and the proliferation of venous wall in the transplanted models were observed after vein transplantation.
RESULTS AND CONCLUSION: All the autogenously graft vein remain patency. The cycloxygenase-2 expression was not obvious in the normal vein and increased significantly in the transplanted vein. The cycloxygenase-2 mRNA expression in the transplanted vein of the experimental group was lower than that of the control group, the thickening degree of the intimal and medial of transplanted vein in the experimental group was lower than that in the control group. Cycloxygenase-2 expression increased significantly in the transplanted vein, and inhibition the cycloxygenase-2 expression can slow down hyperplasia of transplanted vein.