Abstract:

BACKGROUND: The micro-angiogenesis is the key to the survival of the fat cells. Research shows vascular endothelial growth factor and basic fibroblast growth factor can promote blood vessel growth.
OBJECTIVE: To observe the effect of vascular endothelial growth factor and basic fibroblast growth factor on the survival of fat particles after transplantation.
METHODS: Fifty SD rats were divided into five groups, and the autologous greater omentum was transplanted to the rat back, and then added normal saline, 50 μg/L vascular endothelial growth factor, 50 μg/L basic fibroblast growth factor, 50 μg/L vascular endothelial growth factor+50 μg/L basic fibroblast growth factor and 100 μg/L vascular endothelial growth factor+100 μg/L basic fibroblast growth factor, respectively. At 15 and 30 days after transplantation, rats were killed to remove the graft.
RESULTS AND CONCLUSION: The graft residual weight and vascular density in 100 μg/L vascular endothelial growth factor+100 μg/L basic fibroblast growth factor experimental group was significantly higher than those in the other three groups and the difference was significant (P < 0.05), there was no significant difference among the other four groups (P > 0.05). The combination of vascular endothelial growth factor and basic fibroblast growth factor can significantly promote the fat particles to survive.