Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (31): 5737-5741.doi: 10.3969/j.issn.2095-4344.2012.31.009

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Percutaneous biopsy of renal allograft: Analysis of pathological and clinical value in 20 cases

Pei Xiang-ke1, 2, Han Yong2, Wang Qiang2, Xu Liang2, Guo Hui3, Shi Bing-yi2, Cai Ming2   

  1. 1Department of Urology, the 281 Hospital of Chinese PLA, Qinhuangdao 066100, Hebei Province, China;
    2Chinese PLA Organ Transplantation Center, the 309 Hospital of Chinese PLA, Beijing 100091, China;
    3Institute of Organ Transplantation, Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
  • Received:2011-12-15 Revised:2011-12-15 Online:2012-07-29 Published:2012-07-29
  • Contact: Cai Ming, Chief physician, Master’s supervisor, Professor, Chinese PLA Organ Transplantation Center, the 309 Hospital of Chinese PLA, Beijing 100091, China caiming@medmail. com
  • About author:Pei Xiang-ke☆, Doctor, Attending physician, Department of Urology, the 281 Hospital of Chinese PLA, Qinhuangdao 066100, Hebei Province, China; Chinese PLA Organ Transplantation Center, the 309 Hospital of Chinese PLA, Beijing 100091, China pxkmail@126.com

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Abstract:

BACKGROUND: To determine the cause of graft renal dysfunction after renal transplantation based on the clinical manifestations, non-invasive examinations and clinical experience is often in trouble, percutaneous renal biopsy can provide important evidence-based theory.
OBJECTIVE: To investigate the clinical significance of renal allograft biopsy.
METHODS: Pathological data of 20 patients with renal allograft biopsy and the clinical outcome of accordingly adjusted treatment were retrospectively analyzed.
RESULTS AND CONCLUSION: Acute rejection occurred in seven cases (35.0%), doubtful acute rejection occurred in two cases (10.0%), doubtful acute rejection combined drug poisoning occurred in one cases (5.0%), drug poisoning occurred in three cases (15.0%), chronic allograft nephropathy occurred in three cases (15.0 %), no obvious abnormality occurred in three cases (15.0%), acute renal tubular necrosis occurred in one case (5.0%). After therapeutic regimen was adjusted, graft function of nine cases (45%) returned to normal, seven cases (35%) improved, three cases (15%) did not change markedly and one case (5%) deteriorated slightly. Renal graft biopsy is important for the etiological diagnosis of the graft function deterioration after kidney transplantation and is in favor of the adjustment of the therapeutic regimen.

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