Bionic polylactic acid/gelatin nanofiber membrane for repairing varicose ulcers in the lower extremities

doi:10.3969/j.issn.2095-4344.1363

Abstract

Abstract:

BACKGROUND: Insufficient effective treatments lead to protracted course and recurrence of lower extremity venous ulcers, greatly influencing patient’s life. Animal experiments have confirmed that bionic polylactic acid/gelatin nanofiber membrane has advantages in the repair of deficient skin tissue.

OBJECTIVE: To investigate the efficacy of bionic polylactic acid/gelatin nanofiber membrane in the repair of varicose ulcers in the lower extremities.

METHODS: Sixty patients with varicose ulcers in the lower extremities admitted to the First Affiliated Hospital of Anhui Medical University, China from November 2017 to November 2018 were randomly divided into a control group and an experimental group, with 30 cases in each group. All patients were given debridement and basic treatment in the early stage. Patients in the control group received conventional dressing. Patients in the experimental group received bionic polylactic acid/gelatin nanofiber membrane dressing based on conventional dressing. Wound healing rate, healing time, dressing change frequency, wound pain average score, dressing-caused secondary wound score, ease of operation, safety and patient satisfaction were recorded and compared between the two groups every week. At 6 months after wound healing, post-repair effect was evaluated using the Vancouver Scar Rating Scale. This study was approved by the Ethics Committee, First Affiliated Hospital of Anhui Medical University, China (approval No. PJ2018-01-09).

RESULTS AND CONCLUSION: At 28 days after dressing, wound healing rate and patient satisfaction in the experimental group were significantly greater than those in the control group (P < 0.05). Healing time, dressing change frequency, wound pain average score, dressing-caused secondary wound score, and ease of operation in the experimental group were significantly lower than those in the control group (P < 0.05). Six months after wound healing, scale score in the control group was significantly higher than that in the experimental group (P < 0.05). During dressing and 6 months after wound healing, there were no liver and kidney injuries in the two groups. In addition, no reverse reactions such as local allergy were observed in either group. These results suggest that bionic polylactic acid/gelatin nanofiber membrane for repairing ulcers in patients with lower extremity varicose veins is safe and effective. It can greatly shorten the wound healing time, reduce dressing change frequency, mitigate pain and secondary trauma during wound dressing change, and provide the ease of use by clinical medical staff, and improve patient comfort and satisfaction.

Key words: nanofiber membrane, polylactic acid/gelatin, varicose veins of the lower extremities, ulcers, 3D printing, electrospinning, wound, healing

CLC Number:

Chen Hongrang, Shen Yun, Zhang Haitao, Deng Kunxue, Xu Yuanling, Dai Xingliang, Li Yongsheng, Zhang Xinqiong, Xu Tao. Bionic polylactic acid/gelatin nanofiber membrane for repairing varicose ulcers in the lower extremities [J]. Chinese Journal of Tissue Engineering Research, 2019, 23(26): 4217-4224.

Figures/Tables 10

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