Value of erythrocyte distribution width, fibrinogen and D-dimer in predicting the occurrence and development risk of diabetic foot

doi:10.3969/j.issn.2095-4344.1319

Abstract

Abstract:

BACKGROUND: Thrombosis-related indexes red blood cell distribution width, fibrinogen and D-dimer may be the important markers of predicting the occurrence and development of diabetic foot.
OBJECTIVE: To investigate the clinical value of red blood cell distribution width, fibrinogen and D-dimer in predicting the occurrence and development risk of diabetic foot.
METHODS: Eighty-one patients with diabetic foot and 82 patients with type 2 diabetes mellitus, and 67 healthy people were enrolled to conduct respective case-control analysis. The study was in accordance with the ethical guidance of the Third Affiliated Hospital of Southern Medical University. All patients and their relatives signed the informed consents. The red blood cell distribution width, fibrinogen, and D-dimer were compared among groups. The related risk factors of diabetic foot were analyzed by logistic regression. The best cut-off points, sensitivity and specificity of red blood cell distribution width, fibrinogen and D-dimer for predicting the occurrence of diabetic foot were obtained by receiver operating characteristic curve. The correlation of red blood cell distribution width, fibrinogen and D-dimer was analyzed by Spearman correlation analysis.
RESULTS AND CONCLUSION: (1) The red blood cell distribution width, fibrinogen and D-dimer in the diabetic foot group were significantly higher than those in the type 2 diabetes mellitus group and healthy group (P=0.000). (2) Binary logistic regression analysis indicated that elevated fibrinogen was an independent risk factor for diabetic foot (OR=4.253, P=0.046). The correlation coefficients of red blood cell distribution width, fibrinogen, and D-dimer with diabetic foot were 0.616, 0.724 and 0.797, respectively (all P < 0.001). (3) Receiver operating characteristic curve analysis showed that the cut-off points of red blood cell distribution width, fibrinogen and D-dimer for predicting the occurrence of diabetic foot were 40%, 3 g/L and 329 mg/L, with sensitivity of 77.78%, 72.73%, 93.33% and specificity of 71.95%, 92.98% and 88.24%, respectively. (4) To conclude, red blood cell distribution width, fibrinogen and D-dimer have certain clinical significance in predicting the occurrence and development risk of diabetic foot.

Key words: diabetic foot, red blood cell distribution width, fibrinogen, D-dimer, risk

CLC Number:

R446

Huang Yongqing, Shen Jie, Yuan Sijie, Pan Daoyan. Value of erythrocyte distribution width, fibrinogen and D-dimer in predicting the occurrence and development risk of diabetic foot [J]. Chinese Journal of Tissue Engineering Research, 2019, 23(23): 3716-3721.

Figures/Tables 4

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