Genetic characteristics of anterior cruciate ligament rupture susceptibility genes

doi:10.3969/j.issn.2095-4344.0235

Abstract

Abstract:

BACKGROUND: Anterior cruciate ligament rupture (ACLR) is commonly seen in young athletes, which has a great possibility to induce secondary osteoarthritis.
OBJECTIVE: To review ACLR-related genetic researches and summarize the research advances in ACLR susceptibility genes.
METHODS: PubMed database retrieval was conducted for the literature published before January 2017, using search strategy “gene OR genetic OR genetics and cruciate ligament OR ACL”. Finally, 54 articles addressing human ACLR heredity were included.
RESULTS AND CONCLUSION: Totally 70% of ACLR is a result of non-contact mechanism, and genetic factors have been shown to play a role in the occurrence of ACLR. Case-control studies have reported that several ACLR-related genetic loci have been identified in the candidate susceptibility genes, which are involved in bone and joint biology. However, the results are limited in individual assessment for athletes. Thereafter, a further study on the distribution of polymorphic locus of ACLR susceptibility genes in different populations is needed, to reduce selection bias.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Anterior Cruciate Ligament, Knee Joint, Genetics, Genes, Tissue Engineering

CLC Number:

R318

Yan Mo-qi, Han Feng, Guan Zhe-heng, Wang Yi-fan, Lu Ji-hang, Yang Hui-lin, Sun Ye. Genetic characteristics of anterior cruciate ligament rupture susceptibility genes[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(20): 3275-3280.

Figures/Tables 1

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