Correlation of the signaling pathways of bone metabolism and lipid metabolism with bone metabolism related diseases: theoretical advance and research direction

doi:10.3969/j.issn.2095-4344.0231

Abstract

Abstract:

BACKGROUND: Recently, the incidence of metabolic syndrome characterized by obesity, hyperlipidemia, and hyperglycemia is on a rise. Lipid metabolism disorder can lead to bone metabolism disorder, further inducing osteoporosis, bone loss, and osteoarthritis.
OBJECTIVE: To summarize the main pathways between bone metabolism and lipid metabolism, explore the relationship between lipid metabolism and bone metabolism related disease, and provide new therapeutic direction for bone metabolism related diseases.
METHODS: A computer-based search for literature in PubMed and CNKI databases published from January 2000 to July 2017 was performed using the keywords of “bone metabolism, lipid metabolism, bone marrow mesenchymal stem cells, osteoarthritis, osteoporosis” in English and Chinese, respectively. A total of 156 articles were retrieved and 58 eligible articles were in accordance with the inclusion and exclusion criteria after reading the title and abstract.
RESULTS AND CONCLUSIONS: Lipid metabolism interacts with bone metabolism mainly by Wnt/β-catenin, PPARγ, leptin, bone morphogenetic protein, SREBP and oxidative stress pathways. Lipid metabolism can affect bone metabolism related diseases, including osteoporosis, osteoarthritis, and bone softening. Statins can treat osteoporosis and bone loss induced by lipid metabolism disorders through activation of Wnt pathway and inhibition of PPARγ pathway. In the future, we devote ourselves to finding the special target at which lipid metabolism is conducive to treatment of bone metabolic diseases.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Lipid Metabolism Disorders, Osteoarthritis, Osteoporosis, Cystatins, Tissue Engineering

CLC Number:

R318

Bo Mao-sheng1, Zhao Jian-ning1, Hong Ye2. Correlation of the signaling pathways of bone metabolism and lipid metabolism with bone metabolism related diseases: theoretical advance and research direction[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(20): 3269-3274.

Figures/Tables 1

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