Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (25): 4659-4662.doi: 10.3969/j.issn.1673-8225.2012.25.020

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Preparation of elemene transdermal gel and its skin penetration in vitro

Liu Xing-yan1, Liu Hong1, Fan Hai-zhu2, Lin Jing2, Zeng Zhao-wu1, He Zhi-wei1   

  1. 1Guangdong Medical College, Dongguan 523808, Guangdong Province, China;
    2Hangzhou Normal University, Hangzhou 310012, Zhejiang Province, China
  • Received:2011-12-20 Revised:2012-03-22 Online:2012-06-17 Published:2013-11-04
  • Contact: Lin Jing, Assistant investigator, Hangzhou Normal University, Hangzhou 310012, Zhejiang Province, China Zeng Zhao-wu, Associate investigator, Guangdong Medical College, Dongguan 523808, Guangdong Province, China He Zhi-wei, Guangdong Medical College, Dongguan 523808, Guangdong Province, China
  • About author:Liu Xing-yan☆, Doctor, Associate investigator, Guangdong Medical College, Dongguan 523808, Guangdong Province, China lxy0428@126.com

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Abstract:

BACKGROUND: Effect of choosing a suitable carrier material on elemene transdermal properties is the problem of elemene transdermal preparation and need to be resolved first.
OBJECTIVE: To prepare an elemene transdermal gel and to investigate its skin penetration in vitro.
METHODS: An elemene transdermal gel was prepared by using hydrophilic polymer polyvinyl alcohol and sodium carboxymethyl cellulose each with good biocompatibility. In the experimental installation for skin penetration in vitro, the mouse dorsal skin was isolated as a barrier for percutaneous penetration experiments. Percutaneous infiltration quantity of elemene was detected by high resolution gas chromatography.
RESULTS AND CONCLUSION: The ratio of polyvinyl alcohol and scarboxymethyl cellulose showed no significant effect on the transdermal ability of elemene. But their concentration in the gel matrix had a certain influence on the transdermal ability of elemene, and 30% content (total content of polyvinyl alcohol and sodium carboxymethyl cellulose) was optimal. These findings suggest that this kind of transdermal gel can be used as a good carrier for elemene.

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