Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (24): 4467-4470.doi: 10.3969/j.issn.1673-8225.2012.24.020

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Construction of experimental pulpitis models in rabbits

Mao Xiao-quan1, Xing Lu2, Tan Shun2, Wu Duo-rong3, Xu Pu1, Huang Qian1   

  1. 1Hainan Provincial Stomatology Center, 2Department of Pathology, 3Center Laboratory, Affiliated Haikou Hospital Xiangya School of Medicine, Central South University, Haikou 570208, Hainan Province, China
  • Received:2011-11-04 Revised:2011-12-03 Online:2012-06-10 Published:2013-11-05
  • Contact: Xu Pu, Doctor, Professor, Chief physician, Hainan Provincial Stomatology Center, Affiliated Haikou Hospital Xiangya School of Medicine, Central South University, Haikou 570208, Hainan Province, China
  • About author:Mao Xiao-quan★, Master, Associate chief physician, Hainan Provincial Stomatology Center, Affiliated Haikou Hospital Xiangya School of Medicine, Central South University, Haikou 570208, Hainan Province, China horse.m@163.com

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Abstract:

BACKGROUND: Animal models of pulpitis have been established using endotoxin in the past; however, they cannot fully reflect the formation process of clinical pulpitis.
OBJECTIVE: To observe the inflammatory characteristics at different time points of rabbit models of pulpitis induced by Streptococcus mutans.
METHODS: The mandibular anterior teeth of 20 healthy New Zealand rabbits were divided into experiment group and control group. The lingual surfaces of the rabbit mandibular anterior teeth were drilled; normal saline was imported into the control tooth, while Streptococcus mutans was imported into the experiment tooth. Five rabbits were sacrificed on 1, 3, 5 and 7 days after operation, respectively; inflammation outcomes of pulpitis was observed.
RESULTS AND CONCLUSION: Inflammatory reaction in the experiment group was slight on 1 day after operation, and was aggravated gradually on 3, 5 and 7 days after operation, accompanied with vascular hyperemia in the pulp, severe effusion and necrosis of the pulp tissue. Inflammation in the control group was aggravated gradually as time went on; very few necrosis were found in the pulp tissues. These findings indicate that the forming process of pulpitis induced by Streptococcus mutans is more suitable to the pathological features of pulpitis.

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