Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (23): 4335-4338.doi: 10.3969/j.issn.1673-8225.2012.23.030

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Induced differentiation of umbilical cord blood mesenchymal stem cells into neuron-like cells

Chen Lei1, Chen Bing2, Xie Fu-tang1   

  1. 1Department of Neurosurgery, Tianjin Fifth Central Hospital, Tianjin 300451, China;
    2Department of Obstetrics and Gynecology, Nanhui Central Hospital, Pudong New Area, Shanghai 201300, China
  • Received:2012-04-24 Revised:2012-05-10 Online:2012-06-03 Published:2013-11-06
  • About author:Chen Lei☆, M.D., Associated chief physician, Department of Neurosurgery, Tianjin Fifth Central Hospital, Tianjin 300451, China Chenlei1130@163.com

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Abstract:

BACKGROUND: Umbilical cord blood-derived mesenchymal stem cells have similar multipotential differentiation to hematopoietic stem cells and bone marrow mesenchymal stem cells, and can be induced to differentiate into neuron-like cells. However, the success rate of isolation and culture is very low. So it is necessary to search a method for culture of umbilical cord blood-derived mesenchymal stem cells with higher success rate.
OBJECTIVE: To explore the biological characteristics of umbilical cord blood-derived mesenchymal stem cells and to search a method for induced differentiation into neuron-like cells.
METHODS: A computer-based online retrieval of CNKI database was performed to search papers describing induced differentiation of umbilical cord blood-derived mesenchymal stem cells into neuron-like cells published between 2002-2011 using the key words “umbilical cord blood-derived mesenchymal stem cells”, “neural cells”, “induced differentiation” and “cytokines”.
RESULTS AND CONCLUSION: Umbilical cord blood-derived stem cells show similar multipotential differentiation to hematopoietic stem cells and bone marrow mesenchymal stem cells and can be induce-differentiated into neuron-like cells. They are negative for CD34 and therefore are the main marker for differentiating hematopoietic stem cells and bone marrow mesenchymal stem cells. The methods for in vitro induced differentiation of umbilical cord blood-derived mesenchymal stem cells include cell growth factor method, chemical inducers method, growth factors combined with inducers method. Research from China and abroad shows that neuron-like cells induce-differentiated by umbilical cord blood-derived mesenchymal stem cells can be used for treatment of central nervous system diseases, and umbilical cord blood-derived mesenchymal stem cells are a kind of ideal seed cells for repair of nerve injury.

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