BACKGROUND: Platelet lysates to repair bone defects cannot only remove the residual cell structure, reduce immunogenicity, but also retain many growth factors to create the conditions for the allograft or xenograft.
OBJECTIVE: To review the studies that platelets can promote the growth of bone lysis as well as application methods in relevant research.
METHODS: PubMed (2004-01/2011-01) and CBM databases (2004-01/2011-01) were searched by using the keywords of “tissue engineering, bone defect, gene therapy, growth factor” in English and “platelet plasma, bone tissue engineering, platelet lysate, growth factor” in Chinese, respectively. Studies addressing platelet lysate to promote bone regeneration and repair were included, and repetitive studies were excluded.
RESULTS AND CONCLUSION: Totally 340 articles were retrieved, and only 23 articles met the inclusive criteria. Up to now, studies have demonstrated that platelet lysate can promote the proliferation of bone marrow mesenchymal stem cells and osteoblasts. Platelet lysate combined with biological ceramic or autogenous bone can significantly promote the repair of bone defects. Rational use of platelet lysate in bone regeneration and repair is of great significance.

Chen L, Li QJ, Song HP. Effects of brain microvascular endothelial cells and astrocytes following treatment with baicalin on neural stem cell differentiation.Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(20): 3793-3796.