Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (20): 3789-3792.doi: 10.3969/j.issn.1673-8225.2012.20.040

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Molecules and ligands of Wnt signaling pathway involved in the transformation between osteoblasts and osteoclasts

Wang Hui, Chen Xiao-dong
 
  

  1. Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai  200092, China
  • Received:2011-08-14 Revised:2011-10-31 Online:2012-05-13 Published:2012-05-13
  • Contact: Chen Xiao-dong, Chief physician, Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China chenxdmd@163.com
  • About author:Wang Hui★, Studying for master’s degree, Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China wanghuigk@163.com
  • Supported by:

    the Research and Innovation Projects of Shanghai Education Commission, No. 08YZ37*

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Abstract:

BACKGROUND: Wnt signaling pathway regulates the balance of chondrocytes and osteoblasts, chondrocyte proliferation, ossification and degeneration in the degenerative changes of articular cartilage. It has been paid more and more attention.
OBJECTIVE: To summarize the role of Wnt signaling pathway in osteoarthritis.
METHODS: A computer-based online search of Wanfang and PubMed databases was performed for related articles published between 2001 and 2011, using key words of “Wnt, pathway, chondrocyte” in Chinese and English, respectively. A total of 24 articles in Wanfang database and 82 articles of PubMed database were collected, and 25 of them were retained according to inclusion criteria.
RESULTS AND CONCLUSION: A series of proteins and their ligands in secretory Wnt family play an important role in chondrocyte ossification, osteoblast phenotype maintenance and the suppression of bone mesenchymal stem cells pimelosis. The classic Wnt/β-actnin signaling pathway participates in the regulation of osteoarthritis development by activating a series of signal molecules and inhibiting the cross and cascade reactions with other signaling pathways. Meanwhile, the molecules and their ligands in the Wnt signaling pathway are involved in the regulation of chondrocytes and osteoblasts balance, hyperosteogeny and bone reconstruction process.

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