Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (16): 2967-2970.doi: 10.3969/j.issn.1673-8225.2012.16.028

Previous Articles     Next Articles

Meta-analysis of nanocrystalline silver versus silver sulfadiazine in the treatment of burn wounds

Ding Hua-rong, Zhang Xian-fa, Liang Zi-qian, Lin Yuan, Meng Cheng-yue   

  1. Department of Burns and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-09-28 Revised:2011-11-12 Online:2012-04-15 Published:2012-04-15
  • Contact: Zhang Xian-fa, Master, Department of Burns and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China zxianfa2003@ 163.com
  • About author:Ding Hua-rong★, Master, Attending physician, Department of Burns and Plastic Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China 478684979@qq.com
  • Supported by:

    Guangxi Graduate Education Innovation Fund Foundation, No. 2010105981002M187*

PDF

534

Cited

5

Abstract:

BACKGROUND: Nanocrystalline silver (NS) is widely used in the treatment of burn wounds, and many articles have confirmed the effectiveness of NS treatment. However the deficient number of cases impacts the credibility of the articles and relevant evidence-based medicine studies are rare.
OBJECTIVE: To systematic review the effects of NS and nanocrystalline silver (SD-Ag) for the treatment of second-degree burns.
METHODS: Pubmed, science direct (SD), VIP (from 1989 to 2010) and CNKI (from 1979 to 2010) were searched. Randomized controlled trials (RCTs) of NS and SD-Ag for second-degree burns were collected. The methodological quality of the included studies was evaluated, and data analysis was performed using the Cochrane Collaboration's software RevMan 5.1. 
RESULTS AND CONCLUSION: A total of 8 RCTs involving 513 second-degree burns patients were included. Meta analysis of the results was presented: the wound healing time in the NS treatment group was less than that in the control group (SD-Ag group) (P < 0.001). The wound healing rate between NS treatment and control groups were not significantly different at 15 days (MD=7.10, 95%CI＝-2.29 to 16.50, P=0.14). But in reliefing the pain there was statistical difference between the two groups (P < 0.000 01). According to the evidence, treatment for second-degree burns with NS can improve the wound healing rate and relief the pain of wounds. But it still needs a large sample of high-quality randomized controlled studies to be further confirmed.
 

CLC Number: