Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (16): 2922-2926.doi: 10.3969/j.issn.1673-8225.2012.16.017

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Cellular compatibility of biodegradable AZ31B magnesium alloys with fluoride treatment

Jiang Hai-ying1, Yan Zheng-bin1,2, Zhang Zhao3, Ai Hong-jun4   

  1. 1Department of  Stomatology, Daqing Oilfield General Hospital, Daqing  163411, Heilongjiang Province, China; 2School of Stomatology, Jiamusi University, Jiamusi  154007, Heilongjiang Province, China; 3Clinic of Guangzhou Sports Vocational Education and Technical College, Guangzhou  510663, Guangdong Province, China; 4Department of Prosthodontics, the Affiliated Stomatology Hospital of China Medical University, Shenyang  110002, Liaoning Province, China
  • Received:2011-10-17 Revised:2011-12-16 Online:2012-04-15 Published:2012-04-15
  • Contact: author: Ai Hong-jun, Doctoral supervisor, Professor, Department of Prosthodontics, the Affiliated Stomatology Hospital of China Medical University, Shenyang 110002, Liaoning Province, China
  • About author:Jiang Hai-ying★, Master, Attending physician, Department of Stomatology, Daqing Oilfield General Hospital, Daqing 163411, Heilongjiang Province, China wanghaoyu2002@ 126.com
  • Supported by:

    Natural Science and Technology Foundation of Liaoning Province, No.2008079*

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Abstract:

BACKGROUND: As a new type of biodegradable implant material, magnesium and its alloys have attracted much attention owing to their excellent biocompatibility and comprehensive mechanical properties. However, the clinical application of magnesium and its alloys is affected for their inferior corrosion. It is not confirmed whether AZ31B magnesium alloys with fluoride treatment can exhibit good biocompatibility.
OBJECTIVE: To evaluate the cellular compatibility of magnesium alloy materials with different surface fluoride treatments.
METHODS: The induced human bone marrow mesenchymal cells were taken as the testing cells. The leaching liquor of the magnesium alloy materials with no fluoride treatments and fluoride treatments in different time was extracted for cellular compatibility experiment in vitro. The biocompatibility of AZ31B magnesium alloy materials with different fluoride treatments was evaluated.
RESULTS AND CONCLUSION: This experiment showed that compared with the AZ31B magnesium alloys without fluorine treatments, the cell survival rate of the AZ31B magnesium alloys with fluorine treatments was significantly increased; the toxicity of cells was in grade 1 and there was almost no toxicity to cell growth. These findings suggest that the biocompatibility of AZ31B magnesium alloys with fluoride treatments was superior to that of AZ31B magnesium alloys without fluorine treatments.

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