Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (8): 1496-1500.doi: 10.3969/j.issn.1673-8225.2012.08.037

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Occlusion effect comparison of artificial silicone rubber closure devices with different diameters

Zhang Quan-an, Huang Zong-hai, Shi Fu-jun, Chen Fei, Li Jian-guo, Zou Zhao-wei   

  1. Zhujiang Hospital, Southern Medical University, Guangzhou  510282, Guangdong Province, China
  • Received:2011-09-24 Revised:2011-10-24 Online:2012-02-19 Published:2012-02-19
  • Contact: Huang Zong-hai, Professor, Doctoral supervisor, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China drhuangzh@ yahoo.com.cn
  • About author:Zhang Quan-an★, Studying for master’s degree, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China 289230107@qq.com
  • Supported by:

    Technology Plan of Haizhu District in 2009, No. 2009-Y-017*; Technology Plan of Guangzhou in 2009, No. 2009Z1-E251*; Science and Technology Plan of   Guangdong Province in 2009, No. 2009A030200014*; Combination Project of Product-Study- Research of Guangdong Province in 2010, No. 2010B090400423*

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Abstract:

BACKGROUND: Large diameter of the artificial closure device may result in ischema, necrosis and infection because of its severe oppression on tissue around the stoma, while small diameter of the artificial closure device may lead to leakage of the stoma.
OBJECTIVE: To observe the occlusion effects of closure devices with different diameters so as to explore the most appropriate diameter.
METHODS: Colostomy models with diameter of 3.0 cm were prepared in Tibet mini pigs and divided into three groups randomly. The three groups were implanted by artificial silicone rubber closure devices with diameters of 3.0 cm, 3.5 cm, and 4.0 cm respectively.
RESULTS AND CONCLUSION: At 1 week after occlusion, the leakage rate of the 3.0 cm group was obviously higher than those of the 3.5 cm and 4.0 cm groups (P < 0.05), the leakage rate of the 3.0 cm group was obviously higher than that of the 4.0 cm group (P < 0.05, P < 0.05) at 4 and 8 weeks. The leakage rate increased as the diameter increased, however, the leakage rate had no difference at 4 and 8 weeks. The lymphocyte count of the 4.0 cm group was higher than that of the 3.0 cm group at 4 and 8 weeks (P < 0.05, or P < 0.01). The perfusion of the 3.0 cm group had significant difference with baseline level at 50 seconds  (P < 0.05), and the differences of the 3.5 cm and 4.0 cm groups were significant at each time point (P < 0.01). The diameter of artificial silicone rubber closure devices 0.5-1.0 cm bigger than colostomy diameter may achieve the best effect of occlusion and least occlusion complication under the premise without severe leakage.
 

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