Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (8): 1459-1462.doi: 10.3969/j.issn.1673-8225.2012.08.029

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Application of microcarrier culture techniques in bone and cartilage tissue engineering

Ning Bin1, Tian Zhou-bin2, Jia Tang-hong1   

  1. 1Department of Orthopaedics Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan  250013, Shandong Province, China; 2Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan  250013, Shandong Province, China
  • Received:2011-08-15 Revised:2011-10-21 Online:2012-02-19 Published:2012-02-19
  • About author:Ning Bin☆, Doctor, Attending physician, Department of Orthopaedics Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China ningbin@ mail.sdu.edu.cn

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Abstract:

 

BACKGROUND: Proliferation and specific phenotype maintaining of seed cells are the difficulties in bone and cartilage tissue engineering. The microcarrier bioreactor culture system provides a good method to solve this problem.
OBJECTIVE: To analyze the domestic and international development of microcarrier culture of bone and cartilage cells, and to provide the theoretical basis for microcarrier culture of bone and cartilage cells and researches in tissue engineering.
METHODS: A computer-based online search of articles published from 1967 to 2011was performed at November 2010 in PubMed database (http://www.ncbi.nlm.gov/PubMed) and Wanfang database (http://www.wanfangdata.com.cn) using the key words of “microcarrier, cartilage, tissue engineering” in English and in Chinese, respectively. Articles irrelative to this paper, antiquated or repeated literatures were excluded. Totally 32 articles were chosen for further analysis.
RESULTS AND CONCLUSION: Culture conditions of bone and cartilage cells in microcarrier bioreactor culture system can be well regulated to achieve a large number of proliferation and phenotype maintaining of the cells, or even achieve an enhancement of phenotype. This technology has a good potential application in bone and cartilage tissue engineering and clinical work.

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