Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (8): 1463-1466.doi: 10.3969/j.issn.1673-8225.2012.08.030

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Research and application of liposomes in gene therapy 

Jiang Xian-fang, Zhou Nuo   

  1. Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-09-20 Revised:2011-10-15 Online:2012-02-19 Published:2012-02-19
  • Contact: Zhou Nuo, Doctor, Doctoral supervisor, Chief physician, Professor, Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
  • About author:Jiang Xian-fang★, Studying for master’s degree, Physician, Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China jiangmubo@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30760273*, 30960421*;the Natural Science Foundation of Guangxi Zhuang Autonomous Region, No. 0991013Z*

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Abstract:

BACKGROUND: Liposome is a safe and frequently-used genonic vector. But the composition and structure of liposome limit its application and development. Transfection efficiency and treatment effect of the liposome become the most important reference factors in the research of gene therapy.
OBJECTIVE: To review the application and research progress of liposome in gene therapy.
METHODS: CNKI database, CALIS database and KANGJIAN database were searched for articles from 1995 to 2011 with the key words of “liposome, gene, transfection” in Chinese and English.
RESULTS AND CONCLUSION: Liposome as the genonic vector has many advantages in higher security, lower immunogenicity, less toxicity and easy preparation as compared with viral vector. Therefore, it has been successfully applied in many animal experiments in vivo and in vitro. The application of liposome is restricted by lower transfection efficiency and target activity. So the hot spot of study in gene therapy involves in liposome is to improve the transfection efficiency. The better therapeutic effect is obtained by reaching the treatment concentration in target cells or organ.

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