Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (6): 1099-1102.doi: 10.3969/j.issn.1673-8225.2012.06.032

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Prospects of immunologic intervention combined with stem cells transplantation for the treatment of type 1 diabetes

Li Fang, Chen Hui   

  1. Second Hospital of Lanzhou University, Lanzhou  730000, Gansu Province, China
  • Received:2011-08-01 Revised:2011-11-27 Online:2012-02-05 Published:2012-02-05
  • Contact: author: Chen Hui, Doctor, Professor, Chief physician, Second Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China chenhui02@sohu.com
  • About author:Li Fang, Lanzhou University, Lanzhou 730000, Gansu Province, China lifang199093@163.com

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Abstract:

BACKGROUND: Recent studies show that the combination of immunological intervention and stem cells transplantation can maintain a comparatively long time of insulin—independent period and ease the occurrence of diabetic complications, but the mechanisms are still unknown．
OBJECTIVE: To comprehensively analyze the prospects of immunologic intervention combined with stem cells transplantation for the treatment of type 1 diabetes.
METHODS: The articles were retrieved in PubMed database (http://www.ncbi.nlm.nih.gov/pubmed/), CNKI database (http://www.cnki.net), Weipu database (http://www.cqvip.com/index.shtml) and Wanfang database (http://g.wanfangdata.com.cn/) with the key words of “Stem Cells, Diabetes Mellitus, Immunosuppression” in English or “Stem Cells, Diabetes Mellitus” in Chinese. Among 1676 related literatures, articles closely related with stem cells or immunologic intervention in the treatment of diabetes mellitus and doctorial articles were selected. The older literatures and repetitive researches were excluded, a total of 29 English articles were included for further analysis. 
RESULTS AND CONCLUSION: Based on the present status of the research on stem cells transplantation combined with immunologic intervention in the treatment of type 1 diabetes, 29 related literatures at home or abroad were used to research. 
The results showed that the combination of immunologic intervention and stem cells transplantation for the treatment of type 1 diabetes could increase the efficiency of the therapy, reduce the occurrence of complications, and has a good prospect.

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