Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (6): 1103-1106.doi: 10.3969/j.issn.1673-8225.2012.06.033

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Gene therapy and stem cell therapy in chronic wound healing 

Xia Zhang-quan1, 2, Zhang Cong-ji1, Wang Tao3   

  1. 1Department of Stomatology, Southwest Hospital of Third Military Medical University, Chongqing  400038, China; 2Department of Stomatology, the 291 Hospital of Chinese PLA, Baotou  014040, Inner Mongolia Autonomous Region, China; 3State Key Laboratory of Trauma, Burn and Combined Injury, Military Institute of Combined Injury, Third Military Medical University, Chongqing  400038, China
  • Received:2011-07-13 Revised:2011-09-01 Online:2012-02-05 Published:2012-02-05
  • Contact: author: Zhang Cong-ji, Doctor, Associate chief physician, Associate professor, Master’s supervisor, Department of Stomatology, Southwest Hospital of Third Military Medical University, Chongqing 400038, China zhangcongji2@163.com
  • About author:Xia Zhang-quan★, Master, Department of Stomatology, Southwest Hospital of Third Military Medical University, Chongqing 400038, China; Department of Stomatology, the 291 Hospital of Chinese PLA, Baotou 014040, Inner Mongolia Autonomous Region, China xiazq_0@yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30670636*; the Natural Science Foundation of Chongqing, No. 2006BB5095*

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Abstract:

BACKGROUND: A lot of diseases and factors can cause chronic wound or delayed wound healing. Cene theropy and stem cell therapy provide a new way for the treatment of chronic refractory wounds.
OBJECTIVE: To make a review of gene therapy and stem cell therapy in chronic wound healing
METHODS: A search across the databases of Medline (1980 to 2010-12) was performed, with key words of “gene therapy, stem cell therapy, chronic wound”. The literatures published in recent years with strong directions were included, and studies unrelated to the objective were excluded. Combined with our research experience, latest abroad researches were accessed and summed up.
RESULTS AND CONCLUSION: 267 articles were obtained from the preliminary search across the databases, and 33 documents were eventually included in the study. Gene therapy and stem cell therapy, of which theory and technology grow increasingly mature, have supplied two novel techniques to chronic wound healing and may take breakthrough to the treatment of chronic wound healing.

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