Abstract:

BACKGROUND: Recently, Choukroun’s platelet-rich fibrin (PRF) is known as a rich source of autologous cytokines and growth factors, and special attention is paid as a new biomaterial in dental implant bone defect application.
OBJECTIVE: To review experiments and clinical researches of the PRF.
METHODS: A computer-based retrieval was performed by the first author in the CNKI and PubMed databases to search papers published between January 2000 and December 2011 with the key words of “Choukroun’s platelet-rich fibrin, Platelet-rich plasma, dental implant, bone defect, GBR” in Chinese and English. According to inclusion and exclusion criteria, 30 papers were included in the final analysis.
RESULTS AND CONCLUSION: PRF is consist of fibrin network, platelet, granulocyte and so on. PRF is known as blood products with a rich source of osteogenesis factor. PRF has characteristics in simple operation and without other preparations addition. PRF can simulate effetely the formation of fibrin in blood clots under physiological conditions, which is similar to fibrin in human and perfectly avoiding the occurrence of immune rejection and cross-infection. PRF shows a good ability of promoting tissue healing in experiments and clinical researcher. PRF will receive more attention in the field of oral implantology due to low cost, convenient drawing materials and so on.