Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (4): 736-740.doi: 10.3969/j.issn.1673-8225.2012.04.038

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Effects of pulsed electromagnetic field on osteogenic and osteoclastic metabolism  

Zhu Xiao-lu1, Chen Peng2, Tian Jing2   

  1. 1Second Clinical Medical College of Southern Medical University, Guangzhou  510282, Guangdong Province, China; 2Orthopaedic Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou  510282, Guangdong Province, China.
  • Received:2011-10-17 Revised:2011-10-21 Online:2012-01-22 Published:2014-04-04
  • Contact: Tian Jing, Professor, Associate chief physician, Master’supervisor, Orthopaedic Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China Tian_jing6723@yahoo.com.cn
  • About author:Tian Jing, Professor, Associate chief physician, Master’supervisor, Orthopaedic Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China Tian_jing6723@yahoo.com.cn
  • Supported by:

    Sci-Tech Research Project of Guandong Province, No. 2011B031800147*

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Abstract:

BACKGROUND: The pulsed electromagnetic field can influence the osteoblast, osteoclast, and the bone matrix synthesis.
OBJECTIVE: To explore the mechanism of the pulsed electromagnetic field for treatment of osteoporosis in order to promote its clinical application.
METHODS: A computer-based online search of PubMed database, CNKI database, VIP database and Wanfang database from May 1997 to August 2011 was performed to search related articles with the key words of “pulsed electromagnetic fields (PEMFs), bone metabolism, osteoporosis, osteoblast, osteoclast, bone marrow mesenchymal stem cells (BMSCs)” in English and in Chinese by screening titles and abstracts. Articles related to pulsed electromagnetic field were selected. The documents published recently or in authoritative journals in the same field were preferred.
RESULTS AND CONCLUSION: A total of 389 literatures were obtained in initial retrieval, and 46 documents of them concerning the analysis and treatment of aseptic loosening of aseptic prosthesis were involved to summarize according to inclusion criteria. PEMFs can promote osteogenic metabolism, inhibit osteoclastic metabolism, regulate transforming growth factor β and Interleukin 6, promote bone matrix synthesis, improve the micro-environment for bone growth, as well as facilitate proliferation and differentiation of BMSCs. PEMFs have an important clinical value of treatment for osteoporosis and its complications.
 

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