Abstract:

BACKGROUND: There are more and more applications of vertebroplasty and kyphoplasty. However, studies on the comparison of them are few and most of the studies was all the retrospective case analysis with lacking systematic evaluation.
OBJECTIVE: To evaluate the effect of vertebroplasty and kyphoplasty for the treatment of osteoporotic vertebral compression fractures(OVCF).
METHODS: All controlled studies of vertebroplasty and kyphoplasty for the treatment of OVCF were collected. Two reviewers assessed the quality of literatures and extracted data independently to make the systematic evaluation based on the strictly evaluated the quality of the literatures.
RESULTS AND CONCLUSION: Totally 13 literatures including a total of 728 patients met the inclusion criteria. There were no significant differences of the two groups in pain and functional scores (P=0.69, 0.35). Compared with vertebroplasty, kyphotic wedge angle reduction was more significant, and the leakage of bone cement was lower in the kyphoplasty group (P < 0.000 01, 0.000 1). For the risk of new adjacent vertebral fractures, there was no difference between the two groups (P=0.41). Both vertebroplasty and kyphoplasty can significantly reduce pain and improve functional scores, though there is no significant differences between the two groups. Kyphoplasty can improve kyphotic wedge angle well and reduce the leakage of bone cement. The risk of new fractures can not be evaluated for lack of evidence, which need further confirmation by more randomized controlled studies which are design strictly.