Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (3): 409-412.doi: 10.3969/j.issn.1673-8225.2012.03.006

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Nano-chitosan effect on ion-heavy radiation protection and sensitization  

Pan Xiao-jing1, Li Zhen-ya2, Wang Lin1, Wang Min1, Liu Bin1, Zhang Hong3   

  1. 1Lanzhou University, Lanzhou  730000, Gansu Province, China; 2People’s Hospital of Gansu Province, Lanzhou  730000, Gansu Province, China; 3Institute of Modern Physics, Chinese Academy of Science, Lanzhou  730050, Gansu Province, China
  • Received:2011-07-09 Revised:2011-09-02 Online:2012-01-15 Published:2012-01-15
  • Contact: Liu Bin, Professor, Lanzhou University, Lanzhou 730000, Gansu Province, China liubkq@lzu.edu.cn
  • About author:Pan Xiao-jing★, Studying for master’s degree, Lecturer, Lanzhou University, Lanzhou 730000, Gansu Province, China panxj@lzu.edu.cn
  • Supported by:

     the Major State Basic Research Development Program of China (973 Program), No. 2010CB834202*; the National Natural Science Foundation of China (Key Program), No. 10835011*; the National Natural Science Foundation of China (General Program), No. 30770639*; the Scientific Technology Research Project of Gansu Province, No. 0702NKDA045*, 0801NKDA001*;  the Fundamental Research Funds for the Central Universities, No. lzujbky-2011-134*

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Abstract:

BACKGROUND: Chitosan has been proved to enhance immunity and play a radiation protection role.
OBJECTIVE: To investigate nano-chitosan protection effect on osteoblasts MC3T3-E1 cell line and sensitization effect for human nasopharyngeal carcinoma cell line KB radiated by ion-heavy.
METHODS: Radiation protection and sensitization effect was detected by MTT assay.
RESULTS AND CONCLUSION: Proliferation of KB cell line was inhibited by nano-chitosan, and the nano-chitosan showed a dose-dependent effect to the dosage of ion-heavy radiation. To osteoblasts MC3T3-E1 cell line, nano-chitosan showed a protection effect. The nano-chitosan plays the dual role of radiotherapy sensitization and radiation protection on different cells.
 

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