Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (3): 405-408.doi: 10.3969/j.issn.1673-8225.2012.03.005

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Antibacterial performance of nano-silver-zirconium phosphate antibacterial polyurethane

Zou Zhao-wei, Shi Fu-jun, Huang Zong-hai, He Yan, Li Qiang, Chen Fei, Cui Chun-hui   

  1. Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou  510282, Guangdong Province, China
     
  • Received:2011-11-23 Revised:2011-12-09 Online:2012-01-15 Published:2012-01-15
  • Contact: Huang Zong-hai, Professor, Doctoral supervisor, Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China drhuangzh@ yahoo.com.cn
  • About author:Zou Zhao-wei★, Studying for master’s degree, Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China 360094442@qq.com
  • Supported by:

    the Science and Technology Project of Haizhu District in 2009, No. 2009-Y-017*; the Science and Technology Project of Guangzhou in 2009, No. 2009Z1-E251*; the Science and Technology Project of Guangdong Province in 2009, No. 2009A030200014*; the Produce Study Grinds Unifies Project of Guangdong Province in 2010, No. 2010B090400423*

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Abstract:

BACKGROUND: Polyurethane material has excellent physical and chemical performances, good biocompatibility and anti-clotting properties, and is easy to shape. However, artificial organs manufactured using the polyurethane are vulnerable to the invasion of bacteria and other microorganisms.
OBJECTIVE: To explore the effects of nano-silver base inorganic antimicrobial agent on the antibacterial performance of polyurethane.
METHODS: The nano-silver base inorganic antimicrobial agent RHA-2 was added to polyurethane by the mass fractions of 0% (blank control), 0.5%, 1%, 1.5%, 2%, 2.5% and 5%, respectively. Antimicrobial properties of the polyurethane materials against Staphylococcus aureus and Escherichia coli were assayed using the pellicle sticking method.
RESULTS AND CONCLUSION: The polyurethane added with nano-silver base inorganic antimicrobial agents had a good antibacterial effect on Staphylococcus aureus and Escherichia coli. The inhibitory rate against Staphylococcus aureus in the groups containing 0.5%-5% antimicrobial agents were 80.23%, 91.32%, 95.23%, 99.19%, 99.87% and 99.93%, respectively; the inhibitory rate against Escherichia coli in the corresponding groups were 76.70%, 86.96%, 92.92%, 95.43%, 99.34% and 99.87%, respectively. The antimicrobial properties of polyurethane increased significantly with the increasing proportions of the antibacterial agents. These results indicate that nano-silver base inorganic antimicrobial agents can endow the polyurethanes an excellent antibacterial property. From the antimicrobial perspective, the recommended adding proportion of the nano-silver base inorganic antimicrobial agents in the polyurethane is no less than 1.5%.

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