Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (3): 401-404.doi: 10.3969/j.issn.1673-8225.2012.03.004

Previous Articles     Next Articles

Degradation of biodegradable ureteral stent composed of electrospun nanofibers implanted into the muscle  

Zhang Long, Wang Xiao-qing, Jiang Feng-ming, Guan Jing-jing, Wang Chun-xi   

  1. Department of Urology, First Bethune Hospital of Jilin University, Changchun  130021, Jilin Province, China
  • Received:2011-10-21 Revised:2011-11-28 Online:2012-01-15 Published:2012-01-15
  • Contact: Wang Chun-xi, Professor, Chief physician, Doctoral supervisor, Department of Urology, First Bethune Hospital of Jilin University, Changchun 130021, Jilin Province, China chunxi_wang@ 126.com
  • About author:Zhang Long★, Studying for master’s degree, Department of Urology, First Bethune Hospital of Jilin University, Changchun 130021, Jilin Province, China 3709211985@ 163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 50973043*

PDF

517

Abstract:

BACKGROUND: The author has completed the preliminary investigation on degradation of electrospun nanofiber poly lactic acid- glycolic acid copolymer (PLGA) biodegradable ureteral stent material in vitro and found the degradation time of 80/20 PLGA material in urine could meet the clinical needs.
OBJECTIVE: To investigate the degradation properties of 80/20 PLGA electrospun nanofiber ureteral stents implanted in muscle.
METHODS: The 80/20 PLGA electrospun nanofiber ureteral stents were prepared by electrostatic spinning. The degradation properties of the stents in rabbit paravertebral muscle were observed.
RESULTS AND CONCLUSION: Electrospun nanofiber ureteral stents were successfully prepared with a good morphology under scanning electron microscopy. At 10 weeks of degradation of 80/20 PLGA electrospun nanofiber ureteral stents, their mass was 60% of initial mass, and fracture and disintegration of the stents could be seen. Degradation rate of the stents was slightly decreased than that in vitro, but they were still able to meet the clinical needs of biodegradable ureteral stents.
 

CLC Number: