Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (2): 331-335.doi: 10.3969/j.issn.1673-8225.2012.02.032

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Signal transduction and regulation of bone morphogenetic proteins

Wu Li-yang1, Bei Kang-sheng2   

  1. 1Shantou University Medical College, Shantou  515041, Guangdong Province, China;
    2Department of Orthopedics, Yuebei People’s Hospital of Shantou University Medical College, Shaoguan  515026, Guangdong Province, China
  • Received:2011-09-06 Revised:2011-12-03 Online:2012-01-08 Published:2012-01-08
  • Contact: Bei Kang-sheng, Master’s supervisor, Chief physician, Department of Orthopedics, Yuebei People’s Hospital of Shantou University Medical College, Shaoguan 515026, Guangdong Province, China beikangsheng@163.com
  • About author:Wu Li-yang★, Studying for master’s degree, Physician, Shantou University Medical College, Shantou 515041, Guangdong Province, China g_lywu@163.com
  • Supported by:
     the Key Science and Technology Program of Guangdong Province, No. 2005B36001054*
     

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Abstract:

BACKGROUND: Bone morphogenetic protein is a member of transforming growth factor β superfamily. It has a strong induction of bone formation.
OBJECTIVE: To review the function, signal transduction, signal regulation mechanism of bone morphogenetic proteins and the effect of abnormal signal pathway on human disorders.
METHODS: An online search of CNKI and Medline databases was performed for articles published before 2010 (CNKI) or between 1999 and 2010 (Medline) using keywords of “bone morphogenetic proteins, bone morphogenetic proteins receptors, Smads, signal transduction, signaling regulation” in Chinese and English, respectively. Relevant articles were summarized from three aspects of bone morphogenetic protein: the structure and function, the signal transduction pathway and regulation, the relationship between abnormal signal pathway and human disorders. A total of 110 articles were included. According to inclusion and exclusion criteria, a number of 47 articles were retained at last.
RESULTS AND CONCLUSION: Bone morphogenetic proteins play roles mainly through two signal transduction pathways, Smad-dependent pathway and Smad-independent pathway. This process is regulated by numerous extracellular and intracellular proteins. Furthermore, abnormal signaling of bone morphogenetic protein is closely related to some human disorders.

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