Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (1): 148-152.doi: 10.3969/j.issn.1673-8225.2012.01.032

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Stem cells treatment for osteoporosis: Possibility and feasibility

Jia Yi-jie1, Tian Jing2   

  1. 1南方医科大学第二临床医学院，广东省广州市 510282；2南方医科大学附属珠江医院骨科中心，广东省广州市 510282
  • Received:2011-10-10 Revised:2011-11-11 Online:2012-01-01 Published:2012-01-01
  • Contact: Tian Jing, Master, Professor, Associate chief physician, Orthopaedic Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China tian_jing6723@ yahoo.com.cn
  • About author:Jia Yi-jie, Second Medical School of Southern Medical University, Guangzhou 510282, Guangdong Province, Chinajyj0207@yahoo. cn
  • Supported by:

    Science and Technology Planning Project of Guangdong Province, No. 2011B031800147*

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Abstract:

BACKGROUND: Treatment of osteoporosis with drug is not ideal. In recent years, more and more scientists try to use stem cells to treat osteoporosis.
OBJECTIVE: To explore the treatment for stem cells on osteoporosis in order to promote its clinical application.
METHODS: A computer-based online search of PubMed database and CNKI database between May 1997 and October 2011 was performed to search related articles with the key words of “stem cell, osteoporosis, bone metabolism, osteoporosisbone marrow mesenchymal stem cells (BMMSCs), Adipose-derived stem cells (ADSCs)” in English or in Chinese. Literatures related to treatment for stem cells on osteoporosis were selected; in the same field, the articles published lately in authoritative journals were preferred.
RESULTS AND CONCLUSION: A total of 144 literatures were primarily selected, and 50 documents were involved for summary according to inclusion criteria. The treatment for stem cells on osteoporosis was mainly by increasing the number of osteoblasts. Commonly used methods were stem cells transplantation and induced the differentiation of stem cells. Stem cells treatment which has broad application prospects is an essential way for the treatment of osteoporosis, and it can avoid the side effects of drug therapy.

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