Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (1): 143-147.doi: 10.3969/j.issn.1673-8225.2012.01.031

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Intravenous bone marrow mesenchymal stem cells homing pathways

Wang Yang1, 2, Xiao Yang1   

  1. 1Hematology Department, Guangzhou General Hospital of Guangzhou Military  Area Command of Chinese PLA, Guangzhou  510010, Guangdong Province, China; 2Southern Medical University, Guangzhou  510515, Guangdong Province, China
  • Received:2011-10-24 Revised:2011-11-18 Online:2012-01-01 Published:2012-01-01
  • Contact: Xiao Yang, Master’s supervisor, Chief physician, Hematology Department, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou 510010, Guangdong Province, China jdxiao111@163.com
  • About author:Wang Yang★, Studying for master’s degree, Hematology Department, Guangzhou General Hospital of Guangzhou Military Area Command of Chinese PLA, Guangzhou 510010, Guangdong Province, China; Southern Medical University, Guangzhou 510515, Guangdong Province, China 407853954@qq.com

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Abstract:

BACKGROUND: Mesenchymal stem cells (MSCs), as non-hematopoietic multipotent stem cells, are considered as the most promising stem cells for the treatment of a variety of diseases. But their low rate of homing to target tissues and organs limit the therapeutic efficacy when they are used in stem cell therapy.
OBJECTIVE: To investigate intravenous bone marrow MSCs homing phenomena and mechanisms based on analysis of related literatures at home or abroad.
METHODS: A computer-based online search of CNKI database, Wanfang database and PubMed database was performed with key words “Bone marrow mesenchymal stem cells, homing” in Chinese and in English, respectively. And the articles were mainly selected to be the most representative literatures during the last 10 years. Totally 33 literatures were included according to inspection and sorting.
RESULTS AND CONCLUSION: Many studies showed that intravenous bone marrow MSCs interacted with the vessel wall and migrated across the endothelium, homing to many tissues and organs, especially damaged tissue, inflammation and tumor. This article was discussed from the intravenous MSCs homing phenomena and mechanisms. We describe the regulatory signaling molecules and receptors involved, such as chemotatic factor and growth factor, and adhesion molecules

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