Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (1): 153-157.doi: 10.3969/j.issn.1673-8225.2012.01.033

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Differentiation of adipose-derived stem cells into nerve cells and their transplantation for cerebral ischemia

Zhu Yan-fei1, Wang Lin-lin1, Dong Wei-ren2   

  1. 1Southern Medical University, Guangzhou  510515, Guangdong Province, China;2Department of Histology and Embryology, Basic Medical School, Southern Medical University, Guangzhou  510515, Guangdong Province, China
  • Received:2011-07-06 Revised:2011-09-09 Online:2012-01-01 Published:2012-01-01
  • Contact: Dong Wei-ren, Doctor, Professor, Doctoral supervisor, Department of Histology and Embryology, Basic Medical School, Southern Medical University, Guangzhou 510515, Guangdong Province, China wrdong@163.com
  • About author:Zhu Yan-fei, Southern Medical University, Guangzhou 501515, Guangdong Province, China
  • Supported by:

    the Foundation of Talent Young Teachers of Guangdong Universities, No. C1010086*; the Tackle Key Program of Foshan City, No. 201008063*; Medical Disciplinary Project of Foshan Health Bureau, No. 2010177*

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Abstract:

BACKGROUND: Adipose-derived stem cells (ADSCs) from the mesoderm have the potential of multiple differentiations. It can differentiate to neurons under specific environments and then transplant into animal models of cerebral ischemia which can enhance the recovery of neurological function.
OBJECTIVE: To make a review of ADSCs in the treatment of cerebral ischemia, and to analyze current problems and to prospect the future.
METHODS: PubMed, CNKI, CAJ were retrieved by computer with keywords of “adipose-derived stem cells, adipose-tissue derived stem cells, adipose stem cells, differentiation, cerebral ischemia”. The language was limited for English and Chinese. The literatures included clinical research, basic research, and reviews. Repetitive researches were excluded, and 34 documents of them were involved for further analysis.
RESULTS AND CONCLUSION: In recent years, many researches show that ADSCs can promote the neurological function after cerebral ischemia in different degree. But by now there is no report that ADSCs can be induced to mature neurons. How to differentiate to neurons accurately in vivo is a focus of ADSCs in the treatment of cerebral ischemia.

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