Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (1): 158-162.doi: 10.3969/j.issn.1673-8225.2012.01.034

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Development of umbilical cord mesenchymal stem cells applied in bone tissue engineering

Ha Cheng-zhi, Wang Da-wei   

  1. Department of Joint Surgery, Liaocheng People’s Hospital, Liaocheng  252000, Shandong Province, China
  • Received:2011-06-08 Revised:2011-07-20 Online:2012-01-01 Published:2012-01-01
  • Contact: Wang Da-wei, Master’s supervisor, Chief physician, Department of Joint Surgery, Liaocheng People’s Hospital, Liaocheng 252000, Shandong Province, China
  • About author:Ha Cheng-zhi★, Studying for master’s degree, Taishan Medical University, Taian 271016, Shandong Province, China hcz19851013@163.com

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Abstract:

BACKGROUND: In bone tissue engineering, the studies about umbilical cord mesenchymal stem cells (UC-MSCs) as the new seed cells are gradually increased.
OBJECTIVE: To review the isolation, culture, biology characteristics and the carrier used in bone tissue engineering of UC-MSCs.
METHODS: A computer-based online search of literatures published between January 1999 to March 2011 related to the isolation, culture, biology characteristics and the carrier of UC-MSCs was performed in PubMed database and CNKI database using the key words of “umbilical cord stem cell, bone tissue engineering” in English and in Chinese. Finally, 46 articles were included according to inclusion criteria.
RESULTS AND CONCLUSION: UC-MSCs possess multiple properties of embryon and adult stem cells. UC-MSCs have been proved to meet the criteria of MSCs published by the international society for cellular therapy. However, the isolation, culture, and differentiation of UC-MSCs are still unclear. There are many studies on single scaffolds as carrier, the research about composite carrier and injectable carrier may be the hotspot in the future.

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