Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (44): 8350-8354.doi: 10.3969/j.issn.1673-8225.2011.44.046

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Relationship between exercise, senescence and Th1/Th2 cytokine shift

Yang De-hong1, Wei Yong2   

  1. 1Department of Physical Education, Shanghai Institute of Technology, Shanghai  201418, China
    2College of Sport Science, Shanghai University of Sport, Shanghai   200438, China
  • Received:2011-07-07 Revised:2011-08-19 Online:2011-10-29 Published:2011-10-29
  • About author:Yang De-hong★, Master, Lecturer, Department of Physical Education, Shanghai Institute of Technology, Shanghai 201418, China dehongy@126.com
  • Supported by:

    the Young Teacher Foundation of Shanghai Educational Committee, No. 03LQ05*; the Key Discipline Construction Program of Shanghai City, No. S30802*

Abstract:

BACKGROUND: Several studies have shown that Th1/Th2 cytokine shift exists during the process of aging and disease.
OBJECTIVE: To review and analyze the research about aging and immune cytokines and Th1/Th2 differentiation, aging and Th1/Th2 type cytokines, the possible role of Th1/Th2 cytokines balance in anti-aging.
METHODS: A computer-based retrieval was performed in PubMed (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang database (http://www.wanfangdata.com.cn) to search papers published between 1990-2011 using the key words “exercise, immune senescence” in Chinese and English. The papers with objective-independent and repetitive contents were excluded, and finally 42 papers were included for final analysis.
RESULTS AND CONCLUSION: Many studies have been done about the hot issue of’ exercise, immunity and aging” including Th1/Th2 balance, and the results also show that exercise can improve some aspects while inhibit anothers of immunity. However, the exact biological significance about the changes in the immune system after exercise is not clear. Wether exercise also has a positive effect on the prevention and treatment of the elderly prone diseases, and the specific mechanism of this positive effect need to be further studied.

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