Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (44): 8329-8332.doi: 10.3969/j.issn.1673-8225.2011.44.040

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Liver transplantation for treatment of primary squamous cell carcinoma of the liver in one case

Deng Rong-hai1, Wu Lin-wei1, Wu Cheng-lin1, Wang Dong-ping1, Ju Wei-qiang1, Hu An-bin1, Tai Qiang1, Zhu Xiao-feng1, Han An-jia2, He Xiao-shun1   

  1. 1Organ Transplantation Center, 2Department of Pathology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou  510080, Guangdong Province, China
  • Received:2011-05-07 Revised:2011-07-15 Online:2011-10-29 Published:2011-10-29
  • Contact: He Xiao-shun, Doctor, Professor, Doctoral supervisor, Organ Transplantation Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China gdtrc@163.com
  • About author:Deng Rong-hai☆, Studying for doctorate, Organ Transplantation Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China mddrh81@163.com
  • Supported by:

    the Science and Technology Project of Guangdong Province, No. 2008B030301308*

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Abstract:

BACKGROUND: Primary squamous cell carcinoma of the liver (PSCCL) is rare. Various treatments exhibit poor curative effects and prognosis.
OBJECTIVE: To investigate the short-term curative effects of liver transplantation in treatment of primary squamous cell carcinoma in one case.
METHODS: We analyzed the effect of liver transplantation in treating one case of primary squamous cell carcinoma of the liver in the First Affiliated Hospital of Sun Yat-sen University and retrospectively analyzed the clinical manifestations, tissue origin, therapeutic method and prognosis of 65 cases of the primary squamous cell carcinoma of the liver at home and abroad.
RESULTS AND CONCLUSION: The patient recovered well after liver transplantation, liver function returned to normal, tumor markers such as carcinoembryonic antigen, carbohydrate199 and squamous cell carcinoma antigen decreased to normal levels. Domestic and foreign data show that primary squamous cell carcinoma of the liver presents atypical clinical manifestations, variety of tissue sources, poor efficacy and prognosis of surgical excision, chemotherapy and other treatments. Results from the present case showed that liver transplantation for treatment of primary squamous cell carcinoma of the liver exhibits good curative effects, but further investigations are needed to estimate the long-term effect on such cases.

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