Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (44): 8214-8216.doi: 10.3969/j.issn.1673-8225.2011.44.012

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Living unrelated donor kidney transplantation between spouses

Wang Kai, Qu Qing-shan, Miao Shu-zhai   

  1. Department of Organ Transplantation, People’s Hospital of Zhengzhou, Zhengzhou  450003, Henan Province, China
  • Received:2011-05-19 Revised:2011-06-27 Online:2011-10-29 Published:2011-10-29
  • About author:Wang Kai★, Master, Attending physician, Department of Organ Transplantation, People’s Hospital of Zhengzhou, Zhengzhou 450003, Henan Province, China hywangkai@126.com

Abstract:

BACKGROUND: In recent years, with emergence of laws and regulations of organ transplantation one after another, rapid advance in organ transplantation has been made in China. In addition to cadaveric renal transplantation, the living donor kidney transplantation has been developed. Living unrelated donor kidney transplantation between spouses occupies an important position in the field of organ transplantation.
OBJECTIVE: To observe the curative effects of living unrelated donor kidney transplantation between spouses.
METHODS: 11 cases who received living unrelated donor kidney transplantation between spouses between October 2008 and September 2010 at Department of Organ Transplantation in People’s Hospital of Zhengzhou and 83 cases who concurrently received cadaveric renal transplantation were included in this study. In each group, the recipients received end-to-side anastomosis between donor renal vein and external iliac vein, end-to-end anastomosis between donor renal artery and internal iliac artery, nipple-like anastomosis between ureter and bladder, and tunnel embedding. The immunosuppressive induction scheme included methyllprednisolone and the triple-drug immunosuppressive therapy consisting of calcineurin (tacrolimus or ciclosporin), mycophenolate mofetil, and adrenal cortical hormone was used as basic immunosuppressive scheme. Trough concentration of drug-containing blood was adjusted according to tacrolimus or ciclosporin application dose. Follow up was performed within 6 months after transplantation. Renal function recovery and complications during the early stage after renal transplantation were evaluated.
RESULTS AND CONCLUSION: Incidence of early complications including acute rejections and delayed function recovery of transplant was significantly lower in cases who received living unrelated donor kidney transplantation between spouses than in cases who received cadaveric renal transplantation (P < 0.05). These results indicate that living unrelated donor kidney transplantation between spouses is superior to cadaveric renal transplantation due to sufficient pre-operative preparation, short renal ischemia time, and corresponding immunological tolerance caused by long-term symbiosis between spouses.

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