Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (44): 8193-8196.doi: 10.3969/j.issn.1673-8225.2011.44.007

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Early application of alprostadil after combined liver and kidney transplantation

Shen Bei-li, Miao Shu-zhai, Chen Peng, Peng Yu-hua, Sun Xiao-fen, Cui Hua, Zheng Shan   

  1. Department of Renal Transplantation, Zhengzhou People’s Hospital, Zhengzhou   450003, Henan Province, China
  • Received:2011-05-01 Revised:2011-07-13 Online:2011-10-29 Published:2011-10-29
  • About author:Shen Bei-li, Associate chief physician, Department of Renal Transplantation, Zhengzhou People’s Hospital, Zhengzhou 450003, Henan Province, China 15903711568@139.com

Abstract:

BACKGROUND: Recently the literature has been reported that alprostadil can promote the recovery of graft function and reduce delayed recovery of renal function, acute rejection rate, and mortality.
OBJECTIVE: To observe the effect of the early application of alprostadil after combined liver and kidney transplantation on graft function recovery.
METHODS: A total of 6 cases of combined liver and kidney transplantation patients were selected as experimental group who were given alprostadil 30 μg/d during transplantation and 3 weeks after transplantation. Four cases of combined liver and kidney transplantation patients were selected as control group who were not given alprostadil during transplantation and after transplantation. Urine output, serum creatinine, creatinine clearance, alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, renal vascular resistance index, and biliary drainage volume of patients between two groups after transplantation were observed.
RESULTS AND CONCLUSION: The urine output, creatinine clearance, biliary drainage volume of patients in experimental group after transplantation was higher than that of control group (P < 0.05). Alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin concentration, creatinine concentration, and renal vascular resistance index was lower than that of control group (P  < 0.05). The results have confirmed that alprostadil has a positive significance in the early recovery of transplanted liver and kidney function after combined liver and kidney transplantation.

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