Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (44): 8171-8174.doi: 10.3969/j.issn.1673-8225.2011.44.001

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Interrelations between acute rejection and intercellular adhesion molecule-1 in liver tissue after liver transplantation in Rhesus monkey

Ran Jiang-hua, Zhang Sheng-ning, Liu Jing, Li Zhu, Wu Shu-yuan, Li Lai-bang, Zhang Xi-bing, Zhang Hong-qing, Li Li   

  1. First Department of Hepato- pancreatobiliary Surgery, Affiliated Ganmei Hospital of Kunming Medical College and First Hospital of Kunming City, Research Center of Liver Transplantation, Yunnan Province Institute of Organ Transplantation, Kunming  650011, Yunnan Province, China
  • Received:2011-07-23 Revised:2011-08-31 Online:2011-10-29 Published:2011-10-29
  • Contact: Ran Jiang-hua, First Department of Hepato- pancreatobiliary Surgery, Affiliated Ganmei Hospital of Kunming Medical College and First Hospital of Kunming City, Research Center of Liver Transplantation, Yunnan Province Institute of Organ Transplantation, Kunming 650011, Yunnan Province, China rjh2u@163.com
  • About author:Ran Jiang-hua☆, Doctor, Professor, Master’s supervisor, First Department of Hepato- pancreatobiliary Surgery, Affiliated Ganmei Hospital of Kunming Medical College and First Hospital of Kunming City, Research Center of Liver Transplantation, Yunnan Province Institute of Organ Transplantation, Kunming 650011, Yunnan Province, China
  • Supported by:

    the Major Program of Bureau of Science and Technology of Kunming City, No. 08S100304*

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Abstract:

BACKGROUND: Intercellular adhesion molecule-1 (ICAM-1) level in transplanted tissue would increase when acute rejection occurs.
OBJECTIVE: To investigate the relationship between ICAM-1 and acute rejection of liver transplantation in Rhesus Monkey.
METHODS: Allogenic liver transplantation models were established in Rhesus monkey and then randomly divided into an experimental group (without anti-rejection management after liver transplantation) and a control group (with anti-rejection management during and after liver transplantation).
RESULTS AND CONCLUSION: At 24 and 72 hours after liver transplantation, serum alanine aminotransferase and serum total bilirubin levels were significantly higher in the experimental group than in the control group (P < 0.05 or P  < 0.001). At 12 hours after liver transplantation, transplanted liver in the experimental group showed mild acute rejection, indicating that during acute rejection, liver function changes occur after pathological examination of liver tissue. At 24 and 72 hours after liver transplantation, moderate and severe acute rejection occurred. At 6 hours after liver transplantation, ICAM-1 expression in the vascular endothelial cells, liver cell membrane, and biliary epithelial cells was significantly increased in the experimental group than in the control group (P  < 0.05). In the experimental group, with ICAM-1 expression increasing, rejection was aggravated, indicating that at the early stage of acute rejection, slight changes in liver function and pathological manifestation were observed, and ICAM-1 level was greatly increased. These findings suggest that detection of ICAM-1 level in the cells of transplanted liver tissue would be of significance for early diagnosis of acute rejection after liver transplantation.

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